perfluoromethylbutyl-(4-methylcyclohexyl)amine | 444658-68-8

• 分子结构分类: 有机化合物 - 有机卤素化合物
• 英文名称: perfluoromethylbutyl-(4-methylcyclohexyl)amine
• 英文别名: Perfluoromethylbutyl-(4-methylcyclohexyl)-amine；1,2,2,3,3,4,5,5,6,6-decafluoro-N-(1,1,2,2,3,3,4,4,4-nonafluorobutyl)-N,4-bis(trifluoromethyl)cyclohexan-1-amine
• CAS: 444658-68-8
• 化学式: C₁₂F₂₅N
• 分子量: 633.099
• InChiKey: PTVSGCYKFQKBRR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.8
• 重原子数：
  38
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  26

反应信息

• 作为产物：
  描述：

  1-[2,3,5,6-四氟-4-(三氟甲基)苯基]哌啶 在 氢氟酸 作用下， 反应 10.0h， 以2%的产率得到perfluoromethylbutyl-(4-methylcyclohexyl)amine
  参考文献：
  名称：

  EP1354868

  摘要：

  公开号：

文献信息

• EMULSION OF PERFLUORORGANIC COMPOUNDS FOR MEDICAL PURPOSES, METHOD FOR PRODUCING SAID EMULSION AND METHODS FOR CURING AND PREVENTING DISEASES WITH THE AID OF THE EMULSION
  申请人：Otkrytoe Aktsionernoe Obchestvo Nauchno-Proizvodstvennaya Firma "Perftoran"

  公开号：EP1306083A1

  公开（公告）日：2003-05-02

  An emulsion of perfluoroorganic compounds (PFOCs) with gas-transporting properties for intravascular administration comprises a perfluorocarbon rapidly eliminable from the organism and a perfluorinated tertiary amine slowly eliminable from the organism and further comprises at least three kinds of PFOC admixtures taken in small amounts, which are close in their structure and physicochemical properties to the main components and make up a series of PFOCs with gradually changing properties. The emulsion also contains minor admixtures of H-perfluoroalkanes. Such a composition contributes to the formation of a more homogeneous and stable non-clustered perfluorocarbon phase inside the emulsion particles. The PFOC emulsion is stabilized by a polyoxyethylene-polyoxypropylene copolymer. The formulation of the composition provides stability of the emulsion under storage and on entry into the blood flow, as well as a low viscosity of the PFOC emulsion, which secures a high dynamic oxygen capacity of the preparation and improves the delivery of oxygen to tissues. When preparing the emulsion, the stabilizing agent is heated at a temperature of up to 75°C, all the components are saturated with carbon dioxide gas, and the homogenization is carried out with feeding carbon dioxide gas, whereby the origination of peroxides is minimized and the reactogenicity is thus reduced. It is proposed to use PFOC emulsions as a means for treating air-and fat embolism, obliterating vascular injuries of extremities and poisoning with lipophilic poisons, as well as for preventing toxic injuries caused by various xenobiotics.

  一种用于血管内给药的具有气体传输特性的全氟有机化合物（PFOC）乳剂，由一种可从生物体内快速消除的全氟碳化合物和一种可从生物体内缓慢消除的全氟叔胺组成，还包括至少三种少量的全氟有机化合物混合物，这些混合物的结构和理化性质与主要成分接近，并构成一系列性质逐渐变化的全氟有机化合物。乳液中还含有少量的全氟烷烃外加剂。这种成分有助于在乳液颗粒内部形成更均匀、更稳定的非成团全氟碳化物相。全氟辛烷磺酸乳液由聚氧乙烯-聚氧丙烯共聚物稳定。该组合物的配方使乳液在储存和进入血流时保持稳定，并使全氟辛烷磺酸乳液的粘度较低，从而确保制剂具有较高的动态氧容量，提高向组织输送氧气的能力。 在制备乳剂时，将稳定剂在高达 75°C 的温度下加热，用二氧化碳气体使所有成分达到饱和，并用二氧化碳气体进行均质，从而最大限度地减少过氧化物的产生，降低反应性。 建议使用 PFOC 乳剂治疗空气和脂肪栓塞、四肢血管损伤和亲脂毒物中毒，以及预防各种异种生物造成的毒性损伤。
• PERFLUORONATED CYCLE-CONTAINING TERTIARY AMINES USED AS A BASIS FOR GAS-CONVEYING EMULSIONS AND DEVICE FOR THE PRODUCTION THEREOF
  申请人：Otkrytoe Aktsionernoe Obchestvo Nauchno-Proizvodstvennaya Firma "Perftoran"

  公开号：EP1354868A1

  公开（公告）日：2003-10-22

  Tertiary perfluorocycloamines (TPFCAs)of general formula (1) where n = 1 or 2, m = 2 or 3, X is or wherein at n = 2 X is as the basis for gas transport emulsions. TPFCAs comprise a group of compounds which are close in their physicochemical properties to perfluoro-N-(4-methylcyclohexyl)-piperidine, particularly in the critical temperature of dissolution in hexane, and which are used in a mixture, forming a number of compounds with gradually varying characteristics. Owing to this, a greater homogeneity of the fluorocarbon phase is achievable in the emulsions and it becomes possible to enhance the stability of the emulsion particles stabilized by an ethylene oxide-propylene oxide block copolymer, with the absence of toxicity for large animals. A mixture of TPFCAs is prepared by electrochemical fluorination of n-piperidinoheptafluorotoluene in anhydrous hydrogen fluoride. The use of this mixture of TPFCAs instead of individual perfluoro-N-(4-methylcyclohexyl) piperidine simplifies, speeds up the process for preparing perfluorinated organic compounds, makes it cheaper, and provides conditions for broader application of gas transport emulsions based thereon.

  通式（1）的叔全氟环胺（TPFCAs） 其中 n = 1 或 2，m = 2 或 3、 X 是 或 其中 n = 2 时 X 是 作为气体输送乳剂的基础。 TPFCAs 由一组化合物组成，它们的物理化学性质接近全氟-N-（4-甲基环己基）-哌啶，尤其是在正己烷中的临界溶解温度。因此，碳氟化合物相在乳液中的均匀度更高，而且可以提高由环氧乙烷-环氧丙烷嵌段共聚物稳定的乳液颗粒的稳定性，同时不会对大型动物产生毒性。通过在无水氟化氢中对正哌啶七氟甲苯进行电化学氟化，制备出 TPFCAs 混合物。使用这种 TPFCAs 混合物代替单个的全氟-N-（4-甲基环己基）哌啶，简化和加快了全氟有机化合物的制备过程，使其成本更低，并为在此基础上更广泛地应用气体输送乳剂提供了条件。
• Perfluoronated cycle-containing tertiary amines used as a basis for gas-conveying emulsions and device for the production thereof
  申请人：——

  公开号：US20040054184A1

  公开（公告）日：2004-03-18

  Tertiary perfluorocycloamines (TPFCAs) of general formula (1) 1 where n=1 or 2, m=2 or 3, X is 2 wherein at n=2 X is 3 as the basis for gas transport emulsions. TPFCAs comprise a group of compounds which are close in their physicochemical properties to perfluoro-N-(4-methylcyclohexyl)-piperidine, particularly in the critical temperature of dissolution in hexane, and which are used in a mixture, forming a number of compounds with gradually varying characteristics. Owing to this, a greater homogeneity of the fluorocarbon phase is achievable in the emulsions and it becomes possible to enhance the stability of the emulsion particles stabilized by an ethylene oxide-propylene oxide block copolymer, with the absence of toxicity for large animals. A mixture of TPFCAs is prepared by electrochemical fluorination of n-piperidinoheptafluorotoluene in anhydrous hydrogen fluoride. The use of this mixture of TPFCAs instead of individual perfluoro-N-(4-methylcyclohexyl) piperidine simplifies, speeds up the process for preparing perfluorinated organic compounds, makes it cheaper, and provides conditions for broader application of gas transport emulsions based thereon.

  通式(1)的叔全氟环胺（TPFCAs） 1 其中 n 等于 1 或 2，m 等于 2 或 3、 X 是 2 其中 n 等于 2 X 是 3 作为气体输送乳剂的基础。 TPFCAs 由一组化合物组成，其物理化学性质接近于全氟-N-（4-甲基环己基）-哌啶，特别是在正己烷中的临界溶解温度，它们被混合使用，形成了许多特性逐渐变化的化合物。因此，碳氟化合物相在乳液中的均匀度更高，而且可以提高由环氧乙烷-环氧丙烷嵌段共聚物稳定的乳液颗粒的稳定性，同时不会对大型动物产生毒性。通过在无水氟化氢中对正哌啶七氟甲苯进行电化学氟化，制备出 TPFCAs 混合物。使用这种 TPFCAs 混合物代替单个的全氟-N-（4-甲基环己基）哌啶，简化和加快了全氟有机化合物的制备过程，使其成本更低，并为在此基础上更广泛地应用气体输送乳剂提供了条件。
• US6562872B1
  申请人：——

  公开号：US6562872B1

  公开（公告）日：2003-05-13
• US6878826B2
  申请人：——

  公开号：US6878826B2

  公开（公告）日：2005-04-12