(64)Cu-Dotatate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (64)Cu-Dotatate
• 英文别名: Detectnet；2-[4-[2-[[(2R)-1-[[(4R,7S,10S,13R,16S,19R)-10-(4-aminobutyl)-4-[[(1S,2R)-1-carboxy-2-hydroxypropyl]carbamoyl]-7-[(1R)-1-hydroxyethyl]-16-[(4-hydroxyphenyl)methyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicos-19-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-2-oxoethyl]-7-(carboxylatomethyl)-10-(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetate;copper-64(2+)
• 化学式: C₆₅H₈₈CuN₁₄O₁₉S₂
• 分子量: 1497.63
• InChiKey: IJRLLVFQGCCPPI-NVGRTJHCSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -6.05
• 重原子数：
  101
• 可旋转键数：
  24
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.51
• 拓扑面积：
  554
• 氢给体数：
  15
• 氢受体数：
  26

ADMET

毒理性

• 毒性总结

如果发生辐射过量，应建议患者多喝水并频繁排尿，以增加放射性核素的排泄速率。在某些情况下，可能适当给予利尿剂。

If radiation overdose occurs, patients should be advised to drink plenty of water and to void frequently to increase the rate of elimination of the radionuclide. In certain cases, it may be appropriate to administer a diuretic.

来源:DrugBank

吸收、分配和排泄

• 吸收

铜Cu 64标记的dotatate给药后1-3小时，可以在肾脏、肝脏、肾上腺、脾脏和垂体中检测到放射性。

Radioactivity can be identified in the kidney, liver, adrenal glands, spleen, and pituitary glands 1-3 hours after copper Cu 64 dotatate is administered.

来源:DrugBank

吸收、分配和排泄

• 消除途径

16%至40%的原始放射性在单次静脉给药后6小时在尿液中被检测到。

16% - 40% of the original radioactivity was detected in urine 6 hours after the intravenous administration of a single dose.

来源:DrugBank

反应信息

• 作为产物：
  描述：

  copper dichloride 、 DOTA-Tyr3-octreotate 在 2,5-二羟基苯甲酸 、 sodium acetate 作用下， 以 水 为溶剂， 反应 0.17h， 生成 (64)Cu-Dotatate
  参考文献：
  名称：

  WO2013/29616

  摘要：

  公开号：

文献信息

• Evaluation of Pan-SSTRs Targeted Radioligand [⁶⁴Cu]NOTA-PA1 Using Micro-PET Imaging in Xenografted Mice
  作者：Fei Liu、Xiaoyi Guo、Teli Liu、Xiaoxia Xu、Nan Li、Chiyi Xiong、Chun Li、Hua Zhu、Zhi Yang

  DOI：10.1021/acsmedchemlett.9b00544

  日期：2020.4.9

  Cu-64-labeled new pan-somatostatin receptors (pan-SSTRs) probe PA1 was synthesized, characterized, and evaluated by in vitro and in vivo experiments. [Cu-64]NOTA-PA1 was obtained with high specific activity, high radiochemical purity, and good stability. Cell uptake of [64Cu]NOTA-PA1 was higher than that of [Cu-64]DOTA-TATE in MCF-7, A549, BGC823, and HT-29 cell lines. [64Cu]NOTA-PA1 showed high binding affinity for SSTRs expressed in A549 cells. The in vivo biodistribution and micropositron emission tomography (micro-PET) imaging studies of [64Cu]NOTA-PA1 revealed good detection ability in MCF-7 and A549 xenografted nude mice. The radiosynthesis, quality control, and preliminary biological evaluation of [Cu-64]NOTA-PA1 have broaden the application of radiolabeled octreotide for SSTRs imaging, which could act as a potential multisubtypes targeted radiotracer for imaging SSTRs-positive tumors.