N-[4'-(2-benzyl-1-benzofuran-3-yl)-3-nitrobiphenyl-4-yl]-N-methyl-L-phenylalanine | 796033-76-6

• 分子结构分类: 有机化合物 - 木脂素、新木脂素和相关化合物 - 芳基萘木脂素
• 英文名称: N-[4'-(2-benzyl-1-benzofuran-3-yl)-3-nitrobiphenyl-4-yl]-N-methyl-L-phenylalanine
• 英文别名: (2S)-2-[4-[4-(2-benzyl-1-benzofuran-3-yl)phenyl]-N-methyl-2-nitroanilino]-3-phenylpropanoic acid
• CAS: 796033-76-6
• 化学式: C₃₇H₃₀N₂O₅
• 分子量: 582.656
• InChiKey: ALOFTPNNFBMPOW-XIFFEERXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.1
• 重原子数：
  44
• 可旋转键数：
  9
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  99.5
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Substituted carboxylic acids
  申请人：The Institute for Pharmaceutical Discovery LLC

  公开号：US20040266788A1

  公开（公告）日：2004-12-30

  The present invention relates to compounds and pharmaceutically acceptable salts of formula (I): 1 which are useful in the treatment of metabolic disorders related to insulin resistance or hyperglycemia. These compounds include inhibitors of protein tyrosine phosphatase (PTP-1B) that are useful in the treatment of diabetes and other PTP-1B mediated diseases, such as cancer, neurodegenerative diseases and the like. The compounds of the invention are also useful in pharmaceutical compositions and methods of treating the aforementioned conditions.

  本发明涉及公式（I）的化合物和药学上可接受的盐，其在治疗与胰岛素抵抗或高血糖有关的代谢障碍方面是有用的。这些化合物包括蛋白酪氨酸磷酸酶（PTP-1B）的抑制剂，其在糖尿病和其他PTP-1B介导的疾病（如癌症、神经退行性疾病等）的治疗中是有用的。本发明的化合物也适用于制备药物组合物和治疗上述疾病的方法。
• Substituted Carboxylic Acids
  申请人：Van Zandt Michael C.

  公开号：US20090082392A1

  公开（公告）日：2009-03-26

  The present invention relates to compounds and pharmaceutically acceptable salts of formula (I): which are useful in the treatment of metabolic disorders related to insulin resistance or hyperglycemia. These compounds include inhibitors of protein tyrosine phosphatase (PTP-1B) that are useful in the treatment of diabetes and other PTP-1B mediated diseases, such as cancer, neurodegenerative diseases and the like. The compounds of the invention are also useful in pharmaceutical compositions and methods of treating the aforementioned conditions.

  本发明涉及公式（I）化合物及其药学上可接受的盐，用于治疗与胰岛素抵抗或高血糖有关的代谢性疾病。这些化合物包括蛋白酪氨酸磷酸酶（PTP-1B）的抑制剂，可用于治疗糖尿病和其他PTP-1B介导的疾病，如癌症、神经退行性疾病等。本发明的化合物也适用于制药组合物和治疗上述疾病的方法。
• SUBSTITUTED CARBOXYLIC ACIDS
  申请人：The Institutes for Pharmaceutical Discovery, LLC

  公开号：EP1620420A2

  公开（公告）日：2006-02-01
• JP2006525329A
  申请人：——

  公开号：JP2006525329A

  公开（公告）日：2006-11-09
• US7358364B2
  申请人：——

  公开号：US7358364B2

  公开（公告）日：2008-04-15