magnesium;(2R)-2-acetamido-3-sulfanylpropanoate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: magnesium;(2R)-2-acetamido-3-sulfanylpropanoate
• 化学式: C10H16MgN2O6S2
• 分子量: 348.7
• InChiKey: CDIFCTOKYOUYOT-SCGRZTRASA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -4.04
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  141
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• [EN] N-ACETYL L-CYSTEINE CHELATES AND METHODS FOR MAKING AND USING THE SAME<br/>[FR] CHÉLATES DE N-ACÉTYLE L-CYSTÉINE ET LEURS PROCÉDÉS DE FABRICATION ET D'UTILISATION
  申请人：VIVA PHARMACEUTICAL INC

  公开号：WO2014209412A1

  公开（公告）日：2014-12-31

  A nutritional supplement for a human, the supplement having a chelate comprised of an N-acetyl-L-cysteine ligand bonded to a metal to form a chelate ring. A method for preparing a chelate comprised of N-acetyl-L-cysteine ligand and a metal having the steps of: dissolving an amount of N-acetyl-L-cysteine in an aqueous solution, adding a metal to the aqueous solution, stirring and heating the aqueous solution, and removing the solvent under reduced pressure. A method of treating a human for one or more of oxidative stress, cardiovascular disease, cerebrovascular disease, neurodegenerative diseases, Alzheimer's disease, ADHD, bipolar, schizophrenia, autism, dementia, and HIV in a human comprising administering an effective amount of a composition having N-acetyl-L-cysteine in a chelate formation with a metal. A compound having a chelate formulation with a metal being chelated by an N-acetyl-L-cysteine ligand.

  一种用于人类的营养补充剂，该补充剂具有一个螯合物，由N-乙酰-L-半胱氨酸配体与金属结合形成一个螯合环。一种制备由N-乙酰-L-半胱氨酸配体和金属组成的螯合物的方法包括以下步骤：在水溶液中溶解一定量的N-乙酰-L-半胱氨酸，向水溶液中加入金属，搅拌和加热水溶液，然后在减压下去除溶剂。一种治疗人类氧化应激、心血管疾病、脑血管疾病、神经退行性疾病、阿尔茨海默病、注意力缺陷多动障碍、躁郁症、精神分裂症、自闭症、痴呆症和艾滋病等的方法，包括向人类施用含有N-乙酰-L-半胱氨酸与金属形成螯合物的有效量的组合物。一种具有金属与N-乙酰-L-半胱氨酸配体螯合的螯合制剂的化合物。
• Clinical applications for various thiol complexes and processes for their synthesis
  申请人：CHRONORX, LLC.

  公开号：US20020151533A1

  公开（公告）日：2002-10-17

  This invention relates to the synthesis of certain complexes of cysteine, N-acetylcysteine, N-(2-mercaptopropionyl)glycine, and L-2-oxothiazolidine-4-carboxylate and to the nutritional use of these and other related individual or complexed thiol-contributing glutathione predecessors. Clinical uses for these molecules and complexes in the beneficial modification of various physiological conditions and functions associated with aging, chronic glaucoma, diabetes mellitus, insulin resistance, macular degeneration, neurodegenerative diseases and vasoconstriction are described in particular.

  本发明涉及半胱氨酸、N-乙酰半胱氨酸、N-(2-巯基丙酰)甘氨酸和L-2-氧噻唑啉-4-羧酸的某些络合物的合成，以及这些和其他相关的单独或复合硫醇贡献谷胱甘肽前体的营养用途。特别地，描述了这些分子和复合物在有益地改变与衰老、慢性青光眼、糖尿病、胰岛素抵抗、黄斑变性、神经退行性疾病和血管收缩等各种生理条件和功能相关的临床用途。
• N-acetyl-L-cysteine magnesium salt and pharmaceutical compositions containing it
  申请人：ZAMBON GROUP S.p.A.

  公开号：EP0486921A1

  公开（公告）日：1992-05-27

  A composition useful for the mucolytic therapy of patients predisposed to bronchospasm. This composition contains as active ingredient N-acetyl-cysteine magnesium salt.

  一种可用于支气管痉挛患者粘液溶解治疗的组合物。该组合物的活性成分为 N-乙酰半胱氨酸镁盐。
• Compositions containing vitamin D and magnesium
  申请人：Tucker Matthew Scott

  公开号：US10183031B2

  公开（公告）日：2019-01-22

  Described herein are manufactured compositions that contain vitamin D in an amount from 3500 IU to 5000 IU and magnesium in the form of magnesium L-5-methyltetrahydrofolate in an amount of about 1 mg. A manufactured composition contains vitamin D in an amount from 3500 IU to 5000 IU and magnesium in the form of magnesium L-5-methyltetrahydrofolate in an amount of about 1 mg and N-acetyl-L-cysteine magnesium chelate in the amount of 75 mg. A manufactured composition contains vitamin D in an amount from 3500 IU to 5000 IU and magnesium in the form of magnesium L-5-methyltetrahydrofolate in an amount of about 1 mg and N-acetyl-L-cysteine magnesium chelate in the amount of 75 mg, and iron.

  本文描述的人造组合物含有量为 3500 IU 至 5000 IU 的维生素 D 和量为约 1 毫克的 L-5-甲基四氢叶酸镁形式的镁。一种人造组合物含有含量为 3500 IU 至 5000 IU 的维生素 D 和含量为约 1 毫克的 L-5-甲基四氢叶酸镁和含量为 75 毫克的 N-乙酰-L-半胱氨酸镁螯合物。一种人造组合物含有含量为 3500 IU 至 5000 IU 的维生素 D 和含量为约 1 毫克的 L-5-甲基四氢叶酸镁和含量为 75 毫克的 N-乙酰-L-半胱氨酸镁螯合物形式的镁，以及铁。
• Unit dosage forms for the treatment of herpes simplex
  申请人：——

  公开号：US20010031737A1

  公开（公告）日：2001-10-18

  The components of this invention are chosen because of their complementarity for the prevention or treatment of diseases caused by the herpes simplex virus. L-Lysine favorably increases the physiologic immunomodulation necessary for defense against this virus. Zinc improves and maintains a normal immune response. 2-Deoxy-2-D-glucose and heparin sodium alter the surface interaction between the herpes virus and the cell, preventing fusion and infectivity. N-Acetyl-L-cysteine increases glutathione levels thereby creating a thiol redox barrier to the virus at the cell membrane. Quercetin reduces intracellular replication of the herpes virus and viral infectivity. Ascorbate, in concert with copper and D-&agr;-tocopherol, provides an antioxidant defense against the herpes virus, which tends to lose latency during period of oxidative, free radical excess. Selenium and quercetin also participate in reducing various oxidative stresses. Together the components of this invention provide the potential for improved resistance to, improved recovery from, and a decreased frequency of recurrence of herpes simplex virus infection.

  之所以选择本发明的成分，是因为它们在预防或治疗由单纯疱疹病毒引起的疾病方面具有互补性。L -赖氨酸能有效提高防御这种病毒所需的生理性免疫调节。锌能改善和维持正常的免疫反应。2-Deoxy-2-D-glucose 和肝素钠能改变疱疹病毒与细胞之间的表面相互作用，防止融合和感染。N-乙酰-L-半胱氨酸能提高谷胱甘肽的含量，从而在细胞膜上形成一道阻挡病毒的硫醇氧化还原屏障。槲皮素能减少疱疹病毒在细胞内的复制，降低病毒的感染性。抗坏血酸与铜和 D-&agr;-生育酚共同为疱疹病毒提供抗氧化防御，因为疱疹病毒在氧化和自由基过剩期间往往会失去潜伏性。硒和槲皮素也参与减少各种氧化压力。本发明的这些成分合在一起，有可能提高对单纯疱疹病毒感染的抵抗力，改善恢复情况，并降低复发频率。