(S)-2-(benzylcarbamoyl)-3-methylbutanoic acid | 849737-10-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (S)-2-(benzylcarbamoyl)-3-methylbutanoic acid
• CAS: 849737-10-6
• 化学式: C₁₃H₁₇NO₄
• 分子量: 251.282
• InChiKey: VPXJWGHZGQOOSP-NSHDSACASA-N

物化性质

• 沸点：
  432.6±38.0 °C(Predicted)
• 密度：
  1.182±0.06 g/cm3(Predicted)

反应信息

• 作为反应物：
  描述：

  (S)-2-(benzylcarbamoyl)-3-methylbutanoic acid 在 4-二甲氨基吡啶 、 1-羟基苯并三唑 、 戴斯-马丁氧化剂 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 生成 (S)-3-((S)-2-Benzylcarbamoyloxy-3-methyl-butyrylamino)-5-fluoro-4-oxo-pentanoic acid tert-butyl ester
  参考文献：
  名称：

  Dipeptidyl aspartyl fluoromethylketones as potent caspase inhibitors: peptidomimetic replacement of the P2 α-amino acid by a α-hydroxy acid

  摘要：

  As a continuation of our SAR studies of dipeptidyl aspartyl-fmk as caspase inhibitors, we explored the replacement of the P-2 alpha-amino acid by a peptidomimetic alpha-hydroxy acid. These alpha-carbamoyl-alkylcarbonyl-aspartyl fluoromethylketones were found to be potent caspase inhibitors, and the SAR of these compounds is similar to the corresponding dipeptidyl aspartyl-fmk. MX1153, (S)-3-methyl-2-(phenylcarbamoyl)butanoyl-Asp-fmk, is identified as a potent broad-spectrum caspase inhibitor, and is selective for caspases versus other proteases. MX1153 also has good activity in the cell apoptosis protection assays and is active in the mouse liver apoptosis model. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.01.007
• 作为产物：
  描述：

  L-α-羟基异戊酸 、 异氰酸苄酯 在 吡啶 作用下， 生成 (S)-2-(benzylcarbamoyl)-3-methylbutanoic acid
  参考文献：
  名称：

  Dipeptidyl aspartyl fluoromethylketones as potent caspase inhibitors: peptidomimetic replacement of the P2 α-amino acid by a α-hydroxy acid

  摘要：

  As a continuation of our SAR studies of dipeptidyl aspartyl-fmk as caspase inhibitors, we explored the replacement of the P-2 alpha-amino acid by a peptidomimetic alpha-hydroxy acid. These alpha-carbamoyl-alkylcarbonyl-aspartyl fluoromethylketones were found to be potent caspase inhibitors, and the SAR of these compounds is similar to the corresponding dipeptidyl aspartyl-fmk. MX1153, (S)-3-methyl-2-(phenylcarbamoyl)butanoyl-Asp-fmk, is identified as a potent broad-spectrum caspase inhibitor, and is selective for caspases versus other proteases. MX1153 also has good activity in the cell apoptosis protection assays and is active in the mouse liver apoptosis model. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.01.007