Ala-D-gamma-Glu-Lys-D-Ala-D-Ala

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Ala-D-gamma-Glu-Lys-D-Ala-D-Ala
• 英文别名: (2R)-5-[[(2S)-6-amino-1-[[(2R)-1-[[(1R)-1-carboxyethyl]amino]-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-2-[[(2S)-2-aminopropanoyl]amino]-5-oxopentanoic acid
• 化学式: C₂₀H₃₆N₆O₈
• 分子量: 488.5
• InChiKey: MCIBYIIODNXVSL-MQLXINIDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -7
• 重原子数：
  34
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  243
• 氢给体数：
  8
• 氢受体数：
  10

文献信息

• Pharmaceutical compositions comprising clavulanic acid or derivative thereof for the treatment of sexual disorder
  申请人：Revaax Pharmaceuticals LLC

  公开号：EP2305251A2

  公开（公告）日：2011-04-06

  A β-lactam compound selected from: i) clavulanic acid or a pharmaceutically acceptable salt thereof or an active ester form thereof; or ii) moxalactam or a pharmaceutically acceptable salt thereof or an active ester form thereof, for use in the treatment of a patient in need of relief from a sexual disorder, and for use in the treatment of prostate cancer or benign prostatic hyperplasia.

  一种β-内酰胺化合物，选自 i) 克拉维酸或其药学上可接受的盐或其活性酯形式；或 ii) 莫沙内酰胺或其药学上可接受的盐或其活性酯形式、 用于治疗需要缓解性功能障碍的病人，以及用于治疗前列腺癌或良性前列腺增生症。
• Neurotherapeutic use of carboxypeptidase inhibitors
  申请人：——

  公开号：US20020028761A1

  公开（公告）日：2002-03-07

  Administration of inhibitors of carboxypeptidase E provides significant neurotropic effects in warm-blooded vertebrates evidenced inter alia by anxiolytic and anti-aggressive behavior and enhanced cognition. Certain &bgr;-Lactam antibiotics, most significantly, certain 1-oxa-1-dethia cephems with blood brain barrier transport, exhibit potent therapeutic neurologic activity.

  对温血脊椎动物施用羧肽酶 E 抑制剂具有显著的神经刺激作用，这主要表现在抗焦虑、抗攻击行为和增强认知能力等方面。某些内酰胺类抗生素，尤其是某些具有血脑屏障转运功能的 1-oxa-1-dethia cephems，具有很强的治疗神经系统的活性。
• Neurotherapeutic composition and method therefor
  申请人：——

  公开号：US20030158172A1

  公开（公告）日：2003-08-21

  Neurotherapeutically pharmaceutical effective compositions are prepared using carboxypeptidase E inhibitors. One class of carboxypeptidase E inhibitors found to exhibit significant neurotropic activity are &bgr;-lactam compounds, particularly penam and cephem &bgr;-lactam antibiotics and non-antibiotic derivatives thereof.

  使用羧肽酶 E 抑制剂可以制备出具有神经治疗效果的药物组合物。 已发现具有显著神经刺激活性的一类羧肽酶 E 抑制剂是内酰胺类化合物，特别是 penam 和 cephem 内酰胺类抗生素及其非抗生素衍生物。
• Neurotherapeutic composition and method
  申请人：——

  公开号：US20040229857A1

  公开（公告）日：2004-11-18

  Administration of &bgr;-Lactam compounds, including &bgr;-lactam antibiotics and &bgr;-lactamase inhibitors provides significant neurotropic effects in warm-blooded vertebrates evidenced inter alia by anxiolytic and anti-aggressive behavior modification and enhanced cognition. Therapeutic methods for using such compounds and their pharmaceutical formulations are described.

  内酰胺类化合物，包括内酰胺类抗生素和内酰胺酶抑制剂，对温血脊椎动物具有显著的神经刺激作用，这主要表现在抗焦虑、抗攻击行为的改变和认知能力的增强。本文介绍了使用此类化合物及其药物制剂的治疗方法。
• PHARMACEUTICAL COMPOSITIONS COMPRISING CLAVULANIC ACID OR DERIVATIVE THEREOF FOR THE TREATMENT OF BEHAVIORAL DISEASES
  申请人：Revaax Pharmaceuticals LLC

  公开号：EP1206261A2

  公开（公告）日：2002-05-22