3(R)-Ethyl-4(S)-piperidinessigsaeuremethylester | 35802-17-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3(R)-Ethyl-4(S)-piperidinessigsaeuremethylester
• 英文别名: methyl 2-[(3R,4S)-3-ethylpiperidin-4-yl]acetate
• CAS: 35802-17-6
• 化学式: C₁₀H₁₉NO₂
• 分子量: 185.266
• InChiKey: FBZACEFBSHRTRS-IUCAKERBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Quinoline derivatives, processes for their preparation, their use, pharmaceutical compositions containing them and a method for the preparation of these pharmaceutical compositions
  申请人：ACF CHEMIEFARMA NV

  公开号：EP0030044A1

  公开（公告）日：1981-06-10

  The invention is concerned with novel quinicine and cinchonicine derivatives having cardiovascular activities of the formula or a salt thereof, in which A-B is -CH2-CH2, -CHOH-CH2-, -CH2-CHOH-, -C(O)-CH2-. -CH2-C(O)-, -C(NOR4)-CH2-or -CH2-C(NOR4)-; R1 is hydrogen, hydroxy or lower alkoxy; R2 is ethyl or vinyl; R3 is C2-8 alkyl, C1-8 hydroxyalkyl, lower alkoxy-alkyl or lower alkanoyloxyalkyl, C3-6 cycloalkyl, hydroxycycloalkyl, lower alkoxycycloalkyl or lower alkanoyloxycycloalkyl, cycloalkyl lower alkyl, hydroxy-, lower alkoxy- or lower alkanoyloxycycloalkyl lower alkyl; cyano, cyano lower alkyl, lower alkenyl, lower alkynyl, tetrahydrofuryl, mono- or di-lower alkylamino lower alkyl, mono- or di-lower alkylamino lower hydroxy alkyl; optionally substituted phenyl, phenyl lower alkyl or phenyl hydroxy lower alkyl, optionally substituted diphenyl lower alkyl, optionally substituted phenyl lower alkenyl, optionally substituted benzoyl or benzoyl lower alkyl, optionally substituted heteroaryl or heteroaryl lower alkyl, or optionally substituted heteroaryl or heteroaroyl lower alkyl, R4 is lower alkyl, and Z is hydrogen, lower alkyl or optionally substituted phenyl, or Z and R3 together with the carbon atom to which they are attached form a C3-6 cycloalkyl group, whereby the substituents at the 3- and 4-position of the piperidine ring are in the cis-position, excluding N-[C2-6 alkyl, C2-6 hydroxyalkyl, NN-di-lower alkylamino lower alkyl, optionally substituted C7-11 aralkyl] substituted derivatives of quinicine and cinchonicine. The compounds of the formula may be in the form of their optically active enantiomers and/or their therapeutically acceptable salts. Methods for the preparation of the compounds of the formula are also disclosed and form part of the invention.

  本发明涉及具有心血管活性的新型奎宁和辛可宁衍生物，其式或其盐如下、 其中A-B为-CH2- 、-CHOH- -、- -CHOH-、-C(O)- -。- -C(O)-、-C(NOR4)- -或- -C(NOR4)-；R1 是氢、羟基或低级烷氧基；R2 是乙基或乙烯基；R3 是 C2-8 烷基、C1-8 羟基烷基、低级烷氧基烷基或低级烷酰氧基烷基、C3-6 环烷基、羟基环烷基、低级烷氧基环烷基或低级烷酰氧基环烷基、环烷基低级烷基、羟基-、低级烷氧基-或低级烷酰氧基环烷基低级烷基；氰基、氰基低级烷基、低级烯基、低级炔基、四氢糠基、单-或双-低级烷基氨基低级烷基、单-或双-低级烷基氨基低级羟基烷基；任选取代的苯基、苯基低级烷基或苯基羟基低级烷基，任选取代的二苯基低级烷基，任选取代的苯基低级烯基，任选取代的苯甲酰基或苯甲酰基低级烷基，任选取代的杂芳基或杂芳基低级烷基，或任选取代的杂芳基或杂芳基低级烷基，R4 是低级烷基，Z 是氢、低级烷基或任选取代的苯基，或 Z 和 R3 与它们所连接的碳原子一起形成 C3-6 环烷基，其中哌啶环 3-位和 4-位上的取代基为顺式位，不包括奎宁和辛可宁的 N-[C2-6烷基、C2-6 羟基烷基、NN-二低级烷基氨基低级烷基、任选取代的 C7-11 芳基]取代衍生物。 式中化合物可以是其光学活性对映体和/或其治疗上可接受的盐的形式。 本发明还公开了式化合物的制备方法。
• US3957800A
  申请人：——

  公开号：US3957800A

  公开（公告）日：1976-05-18
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  申请人：——

  公开号：US4472403A

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