4-(4-溴苯基)磺酰基苯酚 | 7402-66-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-(4-溴苯基)磺酰基苯酚
• 英文名称: 4-(4-bromo-benzenesulfonyl)-phenol
• 英文别名: 4-(4-Brom-benzolsulfonyl)-phenol；4-(4-Bromophenyl)sulfonylphenol
• CAS: 7402-66-6
• 化学式: C₁₂H₉BrO₃S
• 分子量: 313.172
• InChiKey: QWJWBOCALGDPED-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  62.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-bromo-4-((4-methoxyphenyl)sulfonyl)benzene 在 氢碘酸 作用下， 生成 4-(4-溴苯基)磺酰基苯酚
  参考文献：
  名称：

  Concerning the Variable Character of the Sulfone Group

  摘要：

  DOI：

  10.1021/ja01595a037

文献信息

• Preparation process of fluorine subsituted aromatic compound
  申请人：Mitsui Chemicals, Inc.

  公开号：EP1013629A1

  公开（公告）日：2000-06-28

  A preparation process of a fluorine substituted aromatic compound comprising reacting an alkali metal or alkali earth metal salt of an aromatic compound having a hydroxy group with an organic fluorinating agent is disclosed. As a representative fluorinating agent, a bis-dialkylaminodifluoromethane compound, for example, 2,2'-difluoro-1,3-dimethylimidazolidine, is exemplified. According to the process, an industrially useful fluorinated aromatic compound, for example, a fluorobenzene, a fluorine substituted benzophenone, a fluorine substituted diarylsulfone can be prepared with ease in economy without specific equipment.

  本发明公开了一种氟取代芳香族化合物的制备工艺，该工艺包括使具有羟基的芳香族化合物的碱金属盐或碱土金属盐与有机氟化剂反应。作为氟化剂的代表，举例说明了一种双二烷基氨基二氟甲烷化合物，例如 2,2'-二氟-1,3-二甲基咪唑烷。 根据该工艺，工业上有用的氟化芳烃化合物，例如氟苯、氟取代的二苯甲酮、氟取代的二元砜，无需特定设备即可轻松制备，经济实惠。
• US5331069A
  申请人：——

  公开号：US5331069A

  公开（公告）日：1994-07-19
• US6242654B1
  申请人：——

  公开号：US6242654B1

  公开（公告）日：2001-06-05
• [EN] POLYMERS WITH REDUCED ESTROGENIC ACTIVITY<br/>[FR] POLYMÈRES À ACTIVITÉ OESTROGÉNIQUE RÉDUITE
  申请人：SOLVAY SPECIALTY POLYMERS USA

  公开号：WO2012160172A1

  公开（公告）日：2012-11-29

  A polymer which comprises recurring units derived from at least one monomer (M) having a general formula (I) Y1-Z1-Q-Z2-Y2 wherein Y1 and Y2, equal or different from each other, are independently selected from a group consisting of OH, SH, C1, Br, NO2 or I; Z1 and Z2, equal or different from each other, independently comprises at least 1 aromatic ring and, Q comprises at least one hydrophilic moiety (H) selected from the group consisting of a sulfone (SO2), a ketone (CO), a phosphine oxide (PO), an ether, a thioether, an ester, an anhydride, a carbonate, an amide, an imide, an imine and an urethane group, and the interatomic distance between Y1 and Y2 is at least 10 Å, the monomer has an EC50 response value to the estrogen receptor a (ERα) equal to or at least 26000 nM.
• Concerning the Variable Character of the Sulfone Group
  作者：H. Harry Szmant、George Suld

  DOI：10.1021/ja01595a037

  日期：1956.7