Methoxypropyl cyanoacrylate | 83460-21-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Methoxypropyl cyanoacrylate
• 英文别名: 3-methoxypropyl 2-cyanoprop-2-enoate
• CAS: 83460-21-3
• 化学式: C₈H₁₁NO₃
• 分子量: 169.18
• InChiKey: PFSVSOOFNDBGMO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  59.3
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• [EN] THERAPEUTIC ACRYLATES AS ENHANCED MEDICAL ADHESIVES<br/>[FR] ACRYLATES THÉRAPEUTIQUES UTILES EN TANT QU'ADHÉSIFS MÉDICAUX AMÉLIORÉS
  申请人：UNIV CARNEGIE MELLON

  公开号：WO2018052936A1

  公开（公告）日：2018-03-22

  Provided herein are therapeutic acrylate compounds useful as medical adhesives, comprising a therapeutic agent covalently linked to a methacrylate or cyanoacrylate moiety. Adhesive compositions and kits, such as liquid sutures and bone cement also are provided along with uses for the compositions.

  本文提供了作为医用粘合剂有用的治疗丙烯酸酯化合物，包括与甲基丙烯酸酯或氰丙烯酸酯基团共价连接的治疗剂。此外还提供了粘合剂组合物和套件，如液体缝合线和骨水泥，以及这些组合物的用途。
• Phosphorylated polymers and conjugates thereof
  申请人：Shalaby Wahba Shalaby

  公开号：US20060127354A1

  公开（公告）日：2006-06-15

  The present invention is directed to absorbable polyesters comprising one or more monophosphate functionality; a conjugate comprising the foregoing polyester and a peptide and/or a bioactive agent; microparticles comprising an absorbable polyester; a conjugate comprising the microparticles and a peptide and/or a bioactive agent; an acylated or alkylated polysaccharide having one or more monophosphate functionality; a conjugate comprising the acylated or alkylated polysaccharide and a peptide and/or a bioactive agent; and pharmaceutical compositions thereof.

  本发明涉及包含一种或多种单磷酸酯功能的可吸收聚酯；包括上述聚酯和肽和/或生物活性剂的共轭物；包含可吸收聚酯的微粒；包括微粒和肽和/或生物活性剂的共轭物；具有一种或多种单磷酸酯功能的酰化或烷基化多糖；包括酰化或烷基化多糖和肽和/或生物活性剂的共轭物；以及其制药组合物。
• Polyester/cyanoacrylate tissue adhesive formulations
  申请人：——

  公开号：US20020116026A1

  公开（公告）日：2002-08-22

  The present invention is directed to bioabsorbable adhesive/hemostatic formulations of a 2-alkoxyalkylcyanoacrylate and liquid or solid polymeric modifiers and adjuvant. The present adhesive formulations are useful as tissue adhesive/sealants, hemostatic agents, and as a means for patching or anastomic coupling of damaged organs.

  本发明涉及一种生物可吸收的2-烷氧基烷基丙烯酸酯和液态或固态聚合物改性剂和辅剂的粘合/止血配方。本发明的粘合剂配方可用作组织粘合剂/密封剂、止血剂，并用作修补或连接受损器官的手段。
• Compositions and methods for treating diverticular disease
  申请人：Hunter L. William

  公开号：US20050277577A1

  公开（公告）日：2005-12-15

  Agents, compositions, and implants are provided herein for treating diverticular disease (e.g., diverticulosis and diverticulitis). In particular, fibrosis-inducing agents, hemostatic agents, and/or anti-infective agents, or compositions containing one or more of these agents are provided for use in methods for treating diverticular disease.

  本文提供治疗结肠憩室病（例如结肠憩室症和结肠憩室炎）的代理人、组合物和植入物。特别地，本文提供诱导纤维化代理人、止血代理人和/或抗感染代理人，或含有这些代理人中的一个或多个的组合物，用于治疗结肠憩室病的方法。
• METHOD FOR PRODUCING PURIFIED 2-CYANOACRYLATE
  申请人：TOAGOSEI CO., LTD.

  公开号：EP1632478A1

  公开（公告）日：2006-03-08

  A method for producing a purified 2-cyanoacrylate is characterized in that distillation is conducted in the presence of a polymerization inhibitor whose boiling point is within ±12°C of the boiling point of the 2-cyanoacrylate. With this method, polymerization of 2-cyanoacrylate can be continuously prevented in the distillate system during distillation of a crude 2-cyanoacrylate, so that a purified 2-cyanoacrylate can be obtained.

  一种生产纯化 2-氰基丙烯酸酯的方法，其特征在于蒸馏是在聚合抑制剂的存在下进行的，聚合抑制剂的沸点在 2-氰基丙烯酸酯沸点的±12°C 范围内。采用这种方法，在蒸馏粗 2-氰基丙烯酸酯时，可持续防止 2-氰基丙烯酸酯在蒸馏体系中聚合，从而获得纯化的 2-氰基丙烯酸酯。