(E)-3-bromo-4-fluorobenzaldehyde oxime

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-3-bromo-4-fluorobenzaldehyde oxime
• 英文别名: 3-Bromo-4-fluorobenzaldehyde oxime；(NE)-N-[(3-bromo-4-fluorophenyl)methylidene]hydroxylamine
• 化学式: C₇H₅BrFNO
• 分子量: 218.025
• InChiKey: BVCUJFUCTMJVTK-ONNFQVAWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  32.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (E)-3-bromo-4-fluorobenzaldehyde oxime 在 N-氯代丁二酰亚胺 作用下， 以 二氯甲烷 为溶剂， 以54 %的产率得到(Z)-3-bromo-4-fluoro-N-hydroxybenzimidoyl chloride
  参考文献：
  名称：

  [EN] PYRROLIDINONE DERIVATIVES AS INHIBITORS OF NF KAPPA B INDUCING KINASE
  [FR] DÉRIVÉS DE PYRROLIDINONE UTILES COMME INHIBITEURS DE LA KINASE D'INDUCTION DE NF-KB

  摘要：

  The present disclosure relates to compounds of Formula (I) that inhibit NIK and pharmaceutical compositions comprising such compounds and methods of using the same. These compounds and pharmaceutical compositions are useful for preventing or treating diseases such as inflammatory disorders and autoimmune disorders.

  公开号：

  WO2023217906A1
• 作为产物：
  描述：

  3-溴-4-氟苯甲醛 在 盐酸羟胺 、 sodium carbonate 作用下， 以 乙醇 、 水 为溶剂， 以93 %的产率得到(E)-3-bromo-4-fluorobenzaldehyde oxime
  参考文献：
  名称：

  [EN] PYRROLIDINONE DERIVATIVES AS INHIBITORS OF NF KAPPA B INDUCING KINASE
  [FR] DÉRIVÉS DE PYRROLIDINONE UTILES COMME INHIBITEURS DE LA KINASE D'INDUCTION DE NF-KB

  摘要：

  The present disclosure relates to compounds of Formula (I) that inhibit NIK and pharmaceutical compositions comprising such compounds and methods of using the same. These compounds and pharmaceutical compositions are useful for preventing or treating diseases such as inflammatory disorders and autoimmune disorders.

  公开号：

  WO2023217906A1

文献信息

• [EN] PYRROLIDINONE DERIVATIVES AS INHIBITORS OF NF KAPPA B INDUCING KINASE<br/>[FR] DÉRIVÉS DE PYRROLIDINONE UTILES COMME INHIBITEURS DE LA KINASE D'INDUCTION DE NF-KB
  申请人：[en]JANSSEN PHARMACEUTICA NV

  公开号：WO2023217906A1

  公开（公告）日：2023-11-16

  The present disclosure relates to compounds of Formula (I) that inhibit NIK and pharmaceutical compositions comprising such compounds and methods of using the same. These compounds and pharmaceutical compositions are useful for preventing or treating diseases such as inflammatory disorders and autoimmune disorders.