5-(5-chloro-2,4-dihydroxyphenyl)-N-((1-(5-(hydroxycarbamoyl)pyrimidin-2-yl)piperidin-4-yl)methyl)-4-(4-methoxyphenyl)isoxazole-3-carboxamide | 1133783-68-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 5-(5-chloro-2,4-dihydroxyphenyl)-N-((1-(5-(hydroxycarbamoyl)pyrimidin-2-yl)piperidin-4-yl)methyl)-4-(4-methoxyphenyl)isoxazole-3-carboxamide
• 英文别名: 5-(5-chloro-2,4-dihydroxyphenyl)-N-[[1-[5-(hydroxycarbamoyl)pyrimidin-2-yl]piperidin-4-yl]methyl]-4-(4-methoxyphenyl)-1,2-oxazole-3-carboxamide
• CAS: 1133783-68-2
• 化学式: C₂₈H₂₇ClN₆O₇
• 分子量: 595.011
• InChiKey: NGABHGIBVCBQRR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  42
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  183
• 氢给体数：
  5
• 氢受体数：
  11

文献信息

• HSP90 INHIBITORS CONTAINING A ZINC BINDING MOIETY
  申请人：Qian Changgeng

  公开号：US20090076006A1

  公开（公告）日：2009-03-19

  The present invention relates to HSP90 inhibitors containing a zinc binding moiety and their use in the treatment of cell proliferative diseases such as cancer. The said derivatives may further act as HDAC inhibitors.

  本发明涉及含有锌结合基团的HSP90抑制剂及其在治疗细胞增殖性疾病如癌症中的应用。所述衍生物还可能作为HDAC抑制剂。
• [EN] HSP90 INHIBITORS CONTAINING A ZINC BINDING MOIETY<br/>[FR] INHIBITEURS DE HSP90 CONTENANT UNE FRACTION DE LIAISON AU ZINC
  申请人：CURIS INC

  公开号：WO2009036012A1

  公开（公告）日：2009-03-19

  The present invention relates to HSP90 inhibitors containing a zinc binding moiety and their use in the treatment of cell proliferative diseases such as cancer. The said derivatives may further act as HDAC inhibitors.