(triphenyl-l5-phosphaneyl)gold(II) 1-carboxy-2-(4-hydroxyphenyl)ethene-1-thiolate | 1013659-07-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: (triphenyl-l5-phosphaneyl)gold(II) 1-carboxy-2-(4-hydroxyphenyl)ethene-1-thiolate
• CAS: 1013659-07-8
• 化学式: C₉H₇O₃S*C₁₈H₁₅AuP
• 分子量: 654.476
• InChiKey: PNLFDYJJXSEEON-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  4.81
• 重原子数：
  33.0
• 可旋转键数：
  5.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  57.53
• 氢给体数：
  2.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  AgNO₃(PPh₃) 、 (triphenyl-l5-phosphaneyl)gold(II) 1-carboxy-2-(4-hydroxyphenyl)ethene-1-thiolate 在 sodium hydroxide 作用下， 以 甲醇 、 水 为溶剂， 反应 24.0h， 以55%的产率得到[AgAu(PPh₃)₂(p-hpspa)]
  参考文献：
  名称：

  Heteronuclear gold(I)–silver(I) sulfanylcarboxylates: Synthesis, structure and cytotoxic activity against cancer cell lines

  摘要：

  Heteronuclear complexes of the type [AgAu(PPh3)(2)(xsPa)] [H(2)xspa = 3-(aryl)-2-sulfanylpropenoic adds; (x = 3-phenyl-; 3-(2-chlorophenyl)-; 3-(o-methoxyphenyl)-; 3-(p-methoxyphenyl)-; 3-(p-hydroxyphenyl)-; 3-(2-furyl)-; 3-(2-thienyl)-; spa = 2-sulfanylpropenoate)] were prepared by reacting the appropriate [Au(PPh3)(Hxspa)] precursor with Ag(PPh3)NO3. The compounds were characterized by spectroscopic methods, (IR; H-1, C-13 and P-31 NMR) and mass spectrometry and the structures of the phenyl and p-methoxyphenyl derivatives were determined by X-ray diffraction. The in vitro antitumor activity against the HeLa-229, A2780 and A2780cis cell lines was determined and compared with that of cisplatin and the equivalent homonuclear gold(I) complexes. (C) 2013 Elsevier Inc. All rights reserved.

  DOI：

  10.1016/j.jinorgbio.2013.10.022
• 作为产物：
  描述：

  三苯基膦氯金 、 3-p-hydroxyphenyl-2-mercaptoacrylic acid 在 potassium hydroxide 作用下， 以 乙醇 、 水 为溶剂， 生成 (triphenyl-l5-phosphaneyl)gold(II) 1-carboxy-2-(4-hydroxyphenyl)ethene-1-thiolate
  参考文献：
  名称：

  Heteronuclear gold(I)–silver(I) sulfanylcarboxylates: Synthesis, structure and cytotoxic activity against cancer cell lines

  摘要：

  Heteronuclear complexes of the type [AgAu(PPh3)(2)(xsPa)] [H(2)xspa = 3-(aryl)-2-sulfanylpropenoic adds; (x = 3-phenyl-; 3-(2-chlorophenyl)-; 3-(o-methoxyphenyl)-; 3-(p-methoxyphenyl)-; 3-(p-hydroxyphenyl)-; 3-(2-furyl)-; 3-(2-thienyl)-; spa = 2-sulfanylpropenoate)] were prepared by reacting the appropriate [Au(PPh3)(Hxspa)] precursor with Ag(PPh3)NO3. The compounds were characterized by spectroscopic methods, (IR; H-1, C-13 and P-31 NMR) and mass spectrometry and the structures of the phenyl and p-methoxyphenyl derivatives were determined by X-ray diffraction. The in vitro antitumor activity against the HeLa-229, A2780 and A2780cis cell lines was determined and compared with that of cisplatin and the equivalent homonuclear gold(I) complexes. (C) 2013 Elsevier Inc. All rights reserved.

  DOI：

  10.1016/j.jinorgbio.2013.10.022