Dibromofluoromethylation of aryl Grignard reagents with dibromodifluoromethane in the presence of LiBr
摘要:
The dibromofluoromethylation of aryl Grignard reagents bearing electron-withdrawing groups with dibromodifluoromethane (CF2Br2) proceeded in the presence of LiBr. The reaction gave the corresponding alpha,alpha-dibromo-alpha-fluorotoluene derivatives through halogen exchange reaction of intermediate difluorobenzyl anions. (C) 2015 Elsevier B.V. All rights reserved.
An efficient and general protocol for the synthesis of diarylsulfones via the metal-free coupling of readily available diaryliodonium salts and arenesulfinates in PEG-400 under microwave irradiation has been developed. Utilizing this metal-free and eco-friendly protocol, we have prepared various diarylsulfones in high yields and shorter reaction times under mild conditions. Furthermore, the coupling
[EN] TRICYCLIC VASOPRESSIN ANTAGONISTS<br/>[FR] ANTAGONISTES DE VASOPRESSINE TRICYCLIQUES
申请人:AMERICAN CYANAMID COMPANY
公开号:WO1996022292A1
公开(公告)日:1996-07-25
(EN) Tricyclic diazepines of Formula (I) wherein A, B, D, E, F, Y, and Z are defined in the specification which compounds have vasopressin and oxytocin antagonist activity.(FR) Diazépines tricycliques de formule (I) dans laquelle A, B, D, E, F, Y et Z sont définis dans la demande, lesdits composés ayant une activité d'antagoniste de la vasopressine et de l'oxytocine.