3-(2-phenyl-6-(thiophen-2-yl)pyridin-4-yl)-phenol | 1227851-94-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3-(2-phenyl-6-(thiophen-2-yl)pyridin-4-yl)-phenol
• 英文别名: 3-(2-Phenyl-6-thiophen-2-ylpyridin-4-yl)phenol
• CAS: 1227851-94-6
• 化学式: C₂₁H₁₅NOS
• 分子量: 329.422
• InChiKey: VNKCREXUIZRWPF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  61.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-Hydroxy-chalkon 、 1-[2-oxo-2-(thiophen-2-yl)ethyl]pyridinium iodide 在 ammonium acetate 、 溶剂黄146 作用下， 以82.3%的产率得到3-(2-phenyl-6-(thiophen-2-yl)pyridin-4-yl)-phenol
  参考文献：
  名称：

  Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure–activity relationship study of hydroxylated 2,4-diphenyl-6-aryl pyridines

  摘要：

  A new series of 2,4-diphenyl-6-aryl pyridines containing hydroxyl group(s) at the ortho, meta, or para position of the phenyl ring were synthesized, and evaluated for topoisomerase I and II inhibitory activity and cytotoxicity against several human cancer cell lines for the development of novel anticancer agents. Structure-activity relationship study revealed that the substitution of hydroxyl group( s) increased topoisomerase I and II inhibitory activity in the order of meta > para > ortho position. Substitution of hydroxyl group on the para position showed better cytotoxicity. (c) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.03.051

文献信息

• Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure–activity relationship study of hydroxylated 2,4-diphenyl-6-aryl pyridines
  作者：Radha Karki、Pritam Thapa、Mi Jeong Kang、Tae Cheon Jeong、Jung Min Nam、Hye-Lin Kim、Younghwa Na、Won-Jea Cho、Youngjoo Kwon、Eung-Seok Lee

  DOI：10.1016/j.bmc.2010.03.051

  日期：2010.5

  A new series of 2,4-diphenyl-6-aryl pyridines containing hydroxyl group(s) at the ortho, meta, or para position of the phenyl ring were synthesized, and evaluated for topoisomerase I and II inhibitory activity and cytotoxicity against several human cancer cell lines for the development of novel anticancer agents. Structure-activity relationship study revealed that the substitution of hydroxyl group( s) increased topoisomerase I and II inhibitory activity in the order of meta > para > ortho position. Substitution of hydroxyl group on the para position showed better cytotoxicity. (c) 2010 Elsevier Ltd. All rights reserved.