4-(2-(3-chlorophenyl)-6-(thiophen-2-yl)pyridin-4-yl)phenol | 1375113-41-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-(2-(3-chlorophenyl)-6-(thiophen-2-yl)pyridin-4-yl)phenol
• 英文别名: 4-[2-(3-Chlorophenyl)-6-thiophen-2-ylpyridin-4-yl]phenol；4-[2-(3-chlorophenyl)-6-thiophen-2-ylpyridin-4-yl]phenol
• CAS: 1375113-41-9
• 化学式: C₂₁H₁₄ClNOS
• 分子量: 363.867
• InChiKey: RKALIWYSIVXCEG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  61.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-乙酰基噻吩 在 ammonium acetate 、 碘 、 溶剂黄146 作用下， 反应 27.0h， 生成 4-(2-(3-chlorophenyl)-6-(thiophen-2-yl)pyridin-4-yl)phenol
  参考文献：
  名称：

  Design, synthesis, and antitumor evaluation of 2,4,6-triaryl pyridines containing chlorophenyl and phenolic moiety

  摘要：

  We have designed and synthesized a series of 2,4,6-triaryl pyridine derivatives containing chlorophenyl and phenolic moeity at 2- and 4- position of the central pyridine, respectively, resulting in a total of 42 compounds. They were evaluated for topoisomerase I and 11 inhibitory activities as well as cytotoxicities against several human cancer cell lines. Most compounds showed better topoisomerase II inhibitory activity compared to topoisomerase 1 inhibitory activity. Compounds 19, 20, 26-28, and 47-50 especially showed stronger topo II inhibitory activity than etoposide. (C) 2012 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2012.03.010

文献信息

• Design, synthesis, and antitumor evaluation of 2,4,6-triaryl pyridines containing chlorophenyl and phenolic moiety
  作者：Pritam Thapa、Radha Karki、Minho Yun、Tara Man Kadayat、Eunyoung Lee、Han Byeol Kwon、Younghwa Na、Won-Jea Cho、Nam Doo Kim、Byeong-Seon Jeong、Youngjoo Kwon、Eung-Seok Lee

  DOI：10.1016/j.ejmech.2012.03.010

  日期：2012.6

  We have designed and synthesized a series of 2,4,6-triaryl pyridine derivatives containing chlorophenyl and phenolic moeity at 2- and 4- position of the central pyridine, respectively, resulting in a total of 42 compounds. They were evaluated for topoisomerase I and 11 inhibitory activities as well as cytotoxicities against several human cancer cell lines. Most compounds showed better topoisomerase II inhibitory activity compared to topoisomerase 1 inhibitory activity. Compounds 19, 20, 26-28, and 47-50 especially showed stronger topo II inhibitory activity than etoposide. (C) 2012 Elsevier Masson SAS. All rights reserved.