4-(4-甲氧基苯氧基)苯甲酰氯 | 68548-50-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-(4-甲氧基苯氧基)苯甲酰氯
• 英文名称: 4-(4-methoxy-phenoxy)-benzoyl chloride
• 英文别名: 4-(4-Methoxy-phenoxy)-benzoylchlorid；4-(4-methoxy phenoxy) benzoyl chloride；4-(4-Methoxyphenoxy)benzoyl chloride
• CAS: 68548-50-5
• 化学式: C₁₄H₁₁ClO₃
• 分子量: 262.693
• InChiKey: ZYKMMAMRXDNPOY-UHFFFAOYSA-N

物化性质

• 熔点：
  36 °C
• 沸点：
  204 °C(Press: 0.3 Torr)
• 密度：
  1.248±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(4-甲氧基苯氧基)苯甲酰氯 在 氢溴酸 作用下， 生成 2-bromo-1-[4-(4-methoxy-phenoxy)-phenyl]-ethanone
  参考文献：
  名称：

  Funke; Favre, Bulletin de la Societe Chimique de France, 1951, p. 832,835

  摘要：

  DOI：
• 作为产物：
  描述：

  4-(4-甲氧基苯基)苯甲酸 在 氯化亚砜 作用下， 以 苯 为溶剂， 生成 4-(4-甲氧基苯氧基)苯甲酰氯
  参考文献：
  名称：

  Phenoxy phenyl pyrrolidine compounds, compositions and methods of use

  摘要：

  公式为：##STR1## 其中R是氢、卤素、低碳基、低氧基或三氟甲基，Y是氢、饱和或不饱和的碳氢基团，可达C.sub.4、羟乙基、羟丙基或羧甲基。这些化合物被用作药物，特别用于治疗脂质代谢紊乱。

  公开号：

  US04161529A1

文献信息

• Catalytic, Enantioselective α‐Alkylation of Azlactones with Nonconjugated Alkenes by Directed Nucleopalladation
  作者：Sri Krishna Nimmagadda、Mingyu Liu、Malkanthi K. Karunananda、De‐Wei Gao、Omar Apolinar、Jason S. Chen、Peng Liu、Keary M. Engle

  DOI：10.1002/anie.201814272

  日期：2019.3.18

  palladium(II)‐catalyzed enantioselective α‐alkylation of azlactones with nonconjugated alkenes is described. The reaction employs a chiral BINOL‐derived phosphoric acid as the source of stereoinduction, and a cleavable bidentate directing group appended to the alkene to control the regioselectivity and stabilize the nucleopalladated alkylpalladium(II) intermediate in the catalytic cycle. A wide range of

  描述了钯（II）催化的内酯与非共轭烯烃的对映选择性α-烷基化。该反应使用手性BINOL衍生的磷酸作为立体诱导的来源，并且在烯烃上附加了可裂解的双齿导向基团，以控制区域选择性并稳定催化循环中的核钯烷基钯（II）中间体。人们发现，在最佳反应条件下，各种各样的内酯都具有相容性，从而能够以高收率和高对映选择性提供带有α，α-二取代的α-氨基酸衍生物的产物。
• Addressing cytotoxicity of 1,4-biphenyl amide derivatives: Discovery of new potent and selective 17β-hydroxysteroid dehydrogenase type 2 inhibitors
  作者：Emanuele Marco Gargano、Enrico Perspicace、Angelo Carotti、Sandrine Marchais-Oberwinkler、Rolf W. Hartmann

  DOI：10.1016/j.bmcl.2015.11.047

  日期：2016.1

  Four different classes of new 17 beta-hydroxysteroid dehydrogenase type 2 (17 beta-HSD2) inhibitors were synthesized, in order to lower the cytotoxicity exhibited by the lead compound A, via disrupting the linearity and the aromaticity of the biphenyl moiety. Compounds 3, 4, 7a and 8 displayed comparable or better inhibitory activity and selectivity, as well as a lower cytotoxic effect, compared to the reference compound A. The best compound 4 (IC50 = 160 nM, selectivity factor = 168, LD50 approximate to 25 mu M) turned out as new lead compound for inhibition of 17 beta-HSD2. (C) 2015 Elsevier Ltd. All rights reserved.
• Synthesis and antiproliferative activity of novel 4-substituted-phenoxy-benzamide derivatives
  作者：Chi-Yu Sun、Yang-Sheng Li、Ai-Long Shi、Ya-Fei Li、Rui-Fang Cao、Huai-Wei Ding、Qing-Qing Yin、Li-Juan Zhang、Hua-Chuan Zheng、Hong-Rui Song

  DOI：10.1016/j.cclet.2015.06.017

  日期：2015.10

  A series of novel 4-substituted-phenoxy-benzamide derivatives bearing an aryl cycloaliphatic amine moiety were synthesized and evaluated for antiproliferative activity against SW620, HT29 and MGC803 cancer cell lines in vitro. The pharmacological data demonstrated that the majority of target compounds exhibited moderate efficacy in HT29 and MGC803 cell lines. Compound 10c showed promising inhibition of hedgehog (Hh) signaling pathway in an Hh-related assay. In addition, the superposition pattern of 10c showed a good fit for a pharmacophoric model generated by Hh inhibitors and provided a basis for further structural optimization. (C) 2015 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
• US4161529A
  申请人：——

  公开号：US4161529A

  公开（公告）日：1979-07-17
• Funke; Favre, Bulletin de la Societe Chimique de France, 1951, p. 832,835
  作者：Funke、Favre

  DOI：——

  日期：——