2-[(1R,3S)-3-(2-(4-methoxy-3-methylphenyl)-5-methyl-oxazol-4-ylmethoxy)-cyclohexyloxymethyl]-6-methyl-benzoic acid | 870539-69-8

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: 2-[(1R,3S)-3-(2-(4-methoxy-3-methylphenyl)-5-methyl-oxazol-4-ylmethoxy)-cyclohexyloxymethyl]-6-methyl-benzoic acid
• 英文别名: 2-[[(1R,3S)-3-[[2-(4-methoxy-3-methylphenyl)-5-methyl-1,3-oxazol-4-yl]methoxy]cyclohexyl]oxymethyl]-6-methylbenzoic acid
• CAS: 870539-69-8
• 化学式: C₂₈H₃₃NO₆
• 分子量: 479.573
• InChiKey: UGRQYHXXUNRXOO-PKTZIBPZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  35
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  91
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Diarylcycloalkyl derivatives, processes for their preparation and their use as pharmaceuticals
  申请人：Glombik Heiner

  公开号：US20050267177A1

  公开（公告）日：2005-12-01

  Diarylcycloalkyl derivatives and their physiologically acceptable salts and physiologically functional derivatives are disclosed. The compounds include those of formula I, in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparation. The compounds typically have lipid- and/or triglyceride-lowering properties and are suitable, for example, for the treatment of disorders of lipid metabolism, of type II diabetes, and of syndrome X.

  公开了二芳基环烷基衍生物及其生理上可接受的盐和生理功能衍生物。这些化合物包括式I的那些，其中基团如所定义的，并公开了它们的生理上可接受的盐和制备过程。这些化合物通常具有降脂和/或三酸甘油酯降低性，并且适用于治疗脂质代谢紊乱、II型糖尿病和X综合征等疾病。
• US7399777B2
  申请人：——

  公开号：US7399777B2

  公开（公告）日：2008-07-15