2-[6-(1-pyrrolidinyl)-3-pyridyl]-4H-1,3-benzothiazine-4-one | 501375-07-1

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: 2-[6-(1-pyrrolidinyl)-3-pyridyl]-4H-1,3-benzothiazine-4-one
• 英文别名: 2-(6-Pyrrolidin-1-ylpyridin-3-yl)-1,3-benzothiazin-4-one
• CAS: 501375-07-1
• 化学式: C₁₇H₁₅N₃OS
• 分子量: 309.392
• InChiKey: SPNCRNDMWSYQQO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  70.9
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• 1,3-BENZOTHIAZINONE DERIVATIVES AND USE THEREOF
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP1424336A1

  公开（公告）日：2004-06-02

  This invention provides a compound represented by the formula (I) : wherein R1 is a hydrogen atom, a halogen atom, hydroxy, nitro, optionally halogenated alkyl, alkoxy optionally having substituents, acyl or amino optionally having substituents; R2 is pyridyl, furyl, thienyl, pyrrolyl, quinolyl, pyrazinyl, pyrimidinyl, pyridazinyl, indolyl, tetrahydroquinolyl or thiazolyl, each of which may have substituents; n is 1 or 2; or a salt. And this invention provides a safe pharmaceutical comprising the compound of the formula (I) , which has an excellent apoptosis inhibitory effect and MIF binding effect, for preventing and/or treating heart disease, nervous degenerative disease, cerebrovascular disease, central nervous infectious disease, traumatorathy, demyelinating disease, bone and articular disease, kidney disease, liver disease, osteomyelodysplasia, AIDS, cancer, and the like.

  这项发明提供了一种由以下式（I）表示的化合物： 其中R1是氢原子、卤素原子、羟基、硝基、可选择具有卤素取代基的烷基、可选择具有取代基的烷氧基、酰基或氨基； R2是吡啶基、呋喃基、噻吩基、吡咯基、喹啉基、吡嗪基、嘧啶基、吡啶并嘧啶基、吲哚基、四氢喹啉基或噻唑基，每种基团可能具有取代基； n为1或2；或其盐。该发明提供了一种安全的药物，包括具有优异的凋亡抑制作用和MIF结合作用的式（I）化合物，用于预防和/或治疗心脏病、神经退行性疾病、脑血管疾病、中枢神经感染性疾病、创伤病变、脱髓鞘疾病、骨骼和关节疾病、肾脏疾病、肝脏疾病、骨髓发育不良、艾滋病、癌症等。
• 1, 3-benzothiazinone derivatives and use thereof
  申请人：Kajino Masahiro

  公开号：US20050032786A1

  公开（公告）日：2005-02-10

  This invention provides a compound represented by the formula (I): wherein R 1 is a hydrogen atom, a halogen atom, hydroxy, nitro, optionally halogenated alkyl, alkoxy optionally having substituents, acyl or amino optionally having substituents; R 2 is pyridyl, furyl, thienyl, pyrrolyl, quinolyl, pyrazinyl, pyrimidinyl, pyridazinyl, indolyl, tetrahydroquinolyl or thiazolyl, each of which may have substituents; n is 1 or 2; or a salt. And this invention provides a safe pharmaceutical comprising the compound of the formula (I), which has an excellent apoptosis inhibitory effect and MIF binding effect, for preventing and/or treating heart disease, nervous degenerative disease, cerebrovascular disease, central nervous infectious disease, traumatorathy, demyelinating disease, bone and articular disease, kidney disease, liver disease, osteomyelodysplasia, AIDS, cancer, and the like.

  该发明提供了一个由式(I)表示的化合物：其中R1是氢原子、卤素原子、羟基、硝基、可选取代卤代烷基、可选取代基的烷氧基、酰基或氨基；R2是吡啶基、呋喃基、噻吩基、吡咯基、喹啉基、吡嗪基、嘧啶基、吡嗪啉基、吲哚基、四氢喹啉基或噻唑基，每个基团都可以有取代基；n为1或2；或其盐。该发明提供了一种安全的药物，包括式(I)化合物，具有出色的抑制细胞凋亡和结合MIF的效果，用于预防和/或治疗心脏病、神经退行性疾病、脑血管疾病、中枢神经感染性疾病、创伤性疾病、脱髓鞘疾病、骨骼和关节疾病、肾脏疾病、肝脏疾病、骨髓发育不良、艾滋病、癌症等疾病。
• ACIDIC HAIR DYE COMPOSITION
  申请人：Kokeguchi Yuki

  公开号：US20090100609A1

  公开（公告）日：2009-04-23

  Provided are acidic hair dye compositions in which the dye has a high permeability into hair, the dye can be applied uniformly, and the composition has excellent staining property, safety and sense of use at the time of hair dyeing. The acidic hair dye compositions of the present invention comprise at least one dibasic acid ester compound represented by general formula I below: wherein, in general formula I, R 1 is an alkylene group which may have a substituent with 2 to 4 carbon atoms, R 2 and R 3 are, independently from each other, an alkyl group which may have a substituent with 1 to 4 carbon atoms, R 4 and R 5 are, independently from each other, hydrogen, methyl group or ethyl group, m and n is, independently from each other, an integer of 0 to 4, wherein m+n≧1 (with the proviso that the case is excluded in which R 2 and R 3 are both ethyl group, and m and n are both 1).
• US7399759B2
  申请人：——

  公开号：US7399759B2

  公开（公告）日：2008-07-15
• US7766978B2
  申请人：——

  公开号：US7766978B2

  公开（公告）日：2010-08-03