N-3-hydroxypalmitoyl ornithine | 62345-84-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-3-hydroxypalmitoyl ornithine
• 英文别名: 5-Azaniumyl-2-(3-hydroxyhexadecanoylamino)pentanoate
• CAS: 62345-84-0
• 化学式: C₂₁H₄₂N₂O₄
• 分子量: 386.575
• InChiKey: UUMBWNXCQGDFKZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  27
• 可旋转键数：
  18
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  117
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• [EN] HUMAN MICROBIOTA DERIVED N-ACYL AMIDES FOR THE TREATMENT OF HUMAN DISEASE<br/>[FR] N-ACYL AMIDES DÉRIVÉS DU MICROBIOTE HUMAIN POUR LE TRAITEMENT D'UNE MALADIE HUMAINE
  申请人：UNIV ROCKEFELLER

  公开号：WO2019006246A1

  公开（公告）日：2019-01-03

  The present invention provides compositions and methods for the modulation of G protein-coupled receptors (GPCRs). The invention provides a genetically engineered cell, wherein the cell expresses a human microbial N-acyl synthase (hm-NAS) gene. In one embodiment, the hm-NAS gene is N-acyl serinol synthase. The invention provides a probiotic composition, the probiotic composition comprises a genetically engineered cell of the invention. The invention provides a method for modulating a G protein-coupled receptor (GPCR) activity in a subject, the method comprises administering to the subject an effective amount of a composition comprising at least one selected from the group consisting of a genetically engineered cell, an hm-NAS gene, and a N-acyl amide.

  本发明提供了用于调节G蛋白偶联受体（GPCRs）的组合物和方法。该发明提供了一种基因工程细胞，其中该细胞表达人类微生物N-酰基合酶（hm-NAS）基因。在一个实施例中，hm-NAS基因是N-酰丝氨醇合酶。该发明提供了一种益生菌组合物，该益生菌组合物包括该发明的基因工程细胞。该发明提供了一种调节受体内G蛋白偶联受体（GPCR）活性的方法，该方法包括向受体施用包含至少选自基因工程细胞、hm-NAS基因和N-酰胺的组合物的有效量。
• COMPOSITION FOR IMPROVING BRAIN FUNCTION
  申请人：Mizkan Group Corporation

  公开号：EP2103304A1

  公开（公告）日：2009-09-23

  Provided is a substance which is a safe material such as a food component and an extract of a natural product and has a stronger effect of ameliorating a cerebral function (effect of ameliorating a metabolism of monoamines as an intracerebral neurotransmitter and ameliorating deterioration in memory and learning due to hypofunction of a cholinergic neuron). The present invention provides a composition for ameliorating a cerebral function, comprising an alkali-stable lipid from an acetic acid bacterium, N-acylsphinganine or N-2'-hydroxypalmitoyl-sphinganine, as an active ingredient.

  本发明提供了一种物质，它是一种安全的材料，如食品成分和天然产物的提取物，并且具有更强的改善脑功能的效果（改善作为脑内神经递质的单胺类物质的代谢，以及改善由于胆碱能神经元功能低下而导致的记忆和学习能力衰退的效果）。本发明提供了一种用于改善大脑功能的组合物，其有效成分包括一种来自醋酸菌的碱稳定脂质、N-酰鞘胺酸或 N-2'-hydroxypalmitoyl-sphinganine 。
• COMPOSITION FOR INHIBITING MUSCLE DAMAGE
  申请人：Mizkan Group Corporation

  公开号：EP2127647A1

  公开（公告）日：2009-12-02

  The present invention aims to provide a composition for protecting a muscle damage having high safety and a stronger muscle damage-protecting effect. The present invention provides a composition for protecting a muscle damage comprising, as an active ingredient, an extract with a lipid-soluble organic solvent of an acetic acid bacterium or preferably an extract with ethyl acetate of an acetic acid bacterium, alkali-stable lipid of an acetic acid bacterium, N-acylsphinganine, sphinganine, amino lipids, or terpenoid compounds. Further, the present invention provides a composition for protecting a muscle damage comprising, as an active ingredient, an extract with a lipid-soluble organic solvent of a vinegar or preferably an extract with ethyl acetate of a vinegar.

  本发明旨在提供一种安全性高、保护肌肉损伤效果更强的保护肌肉损伤的组合物。本发明提供了一种保护肌肉损伤的组合物，其有效成分包括醋酸菌的脂溶性有机溶剂提取物或优选醋酸菌的乙酸乙酯提取物、醋酸菌的碱稳定脂质、N-酰鞘胺碱、鞘氨醇、氨基脂质或萜类化合物。此外，本发明还提供了一种用于保护肌肉损伤的组合物，该组合物的活性成分包括醋的脂溶性有机溶剂提取物，或优选醋的乙酸乙酯提取物。
• HUMAN MICROBIOTA DERIVED N-ACYL AMIDES FOR THE TREATMENT OF HUMAN DISEASE
  申请人：The Rockefeller University

  公开号：EP3648769A1

  公开（公告）日：2020-05-13
• COMPOSITION FOR AMELIORATING CEREBRAL FUNCTION
  申请人：Fukami Hiroyuki

  公开号：US20100028465A1

  公开（公告）日：2010-02-04

  Provided is a substance which is a safe material such as a food component and an extract of a natural product and has a stronger effect of ameliorating a cerebral function (effect of ameliorating a metabolism of monoamines as an intracerebral neurotransmitter and ameliorating deterioration in memory and learning due to hypofunction of a cholinergic neuron). The present invention provides a composition for ameliorating a cerebral function, comprising an alkali-stable lipid from an acetic acid bacterium, N-acylsphinganine or N-2′-hydroxypalmitoyl-sphinganine, as an active ingredient.