Diethyl 2-[3-(3,5-dimethoxyphenoxy)-2-oxopropylidene]propanedioate | 1177010-17-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Diethyl 2-[3-(3,5-dimethoxyphenoxy)-2-oxopropylidene]propanedioate
• CAS: 1177010-17-1
• 化学式: C₁₈H₂₂O₈
• 分子量: 366.368
• InChiKey: VNHPNQYIUOTRFD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  26
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  97.4
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  Diethyl 2-[3-(3,5-dimethoxyphenoxy)-2-oxopropylidene]propanedioate 在 (S,S)-(-)-2,2'-异亚丙基双(4-叔丁基-2-恶唑啉) 作用下， 以 四氢呋喃 为溶剂， 生成 diethyl 2-[(4R)-5,7-dimethoxy-3-oxo-4H-chromen-4-yl]propanedioate 、 diethyl 2-[(4R)-5,7-dimethoxy-3-oxo-4H-chromen-4-yl]propanedioate
  参考文献：
  名称：

  Enantioselective Friedel–Crafts reactions of ethenetricarboxylates and substituted pyrroles and furans and intramolecular reaction of benzene derivatives

  摘要：

  Compared to enantioselective Friedel-Crafts reactions of indoles, reactions of alkylidene malonates with monocyclic aromatic compounds generally proceed with low enantioselectivity. The Friedel-Crafts reactions of ethenetricarboxylates 1 and monocyclic heteroaromatic compounds, such as substituted pyrroles and furans were investigated. The reaction of 1 with 2,4-dimethylpyrrole in the presence of a chiral bis-oxazoline-copper(II) complex (10 mol %) in tetrahydrofuran at room temperature gave alkylated products in up to 72% ee. The reaction of 1 with 2-substituted furans gave alkylated products in 46-62% ee. The absolute stereochemistry of the furan Friedel-Crafts product 7e was determined by transformation to the known 2,3-dimethylbutyric acid. The intramolecular reaction of benzene derivatives gave cyclized products up to 56% ee. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2009.05.016