3,4-Diacetoxy-phenylalanin | 28101-59-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3,4-Diacetoxy-phenylalanin
• 英文别名: DL-β-(3,4-Diacetoxyphenyl)alanin；3,4-diacetoxy-phenylalanine；2-Amino-3-(3,4-diacetyloxyphenyl)propanoic acid
• CAS: 28101-59-9
• 化学式: C₁₃H₁₅NO₆
• 分子量: 281.265
• InChiKey: COWCOMKBMUTCGD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.5
• 重原子数：
  20
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  116
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  乙酰氯 、 alkaline earth salt of/the/ methylsulfuric acid 生成 3,4-Diacetoxy-phenylalanin
  参考文献：
  名称：

  Harwood; Cassidy, Journal of the American Chemical Society, 1957, vol. 79, p. 4360,4362

  摘要：

  DOI：

文献信息

• Biocompatible Agent for Dispersing Nanoparticles into an Aqueous Medium Using Mussel Adhesive Protein-Mimetic Polymer
  申请人：Hyeon Taeghwan

  公开号：US20130272965A1

  公开（公告）日：2013-10-17

  Provided are a mussel adhesive protein-mimetic dispersion stabilizing agent to disperse nanoparticles in an aqueous medium, a colloidal solution including nanoparticles dispersed and stabilized by the dispersion stabilizing agent, and a contrast agent including the colloidal solution. More particularly, the mussel adhesive protein-mimetic dispersion stabilizer is a polyethyleneimine-graft-(poly-ethyleneglycol;polyDOPA) PEI-graft-(PEG;PDOPA). The graft polymer is formed of two parts. One is polyethyleneglycol grafted with a polyethyleneime which has an affinity to an aqueous medium, and the other is polyDOPA which has an affinity to the surface of nanoparticles. Because of those characteristics, the stabilizer shows a stable dispersion of nano particles in the aqueous medium.
• US9169355B2
  申请人：——

  公开号：US9169355B2

  公开（公告）日：2015-10-27
• [EN] MRI CONTRAST AGENT FOR LYMPHOGRAPHY BASED ON IRON OXIDE NANOPARTICLES AND METHOD FOR IMAGING LYMPH NODE USING THE SAME<br/>[FR] AGENT DE CONTRASTE D'IRM POUR LYMPHOGRAPHIE À BASE DE NANOPARTICULES D'OXYDE DE FER ET MÉTHODE POUR L'IMAGERIE D'UN NOEUD LYMPHATIQUE UTILISANT CELUI-CI
  申请人：HANWHA CHEMICAL CORP

  公开号：WO2012177039A2

  公开（公告）日：2012-12-27

  Provided are a contrast agent for contrast imaging lymph node, which includes iron oxide nanoparticles dispersed and stabilized in an aqueous medium by a mussel adhesive protein-mimetic copolymer, a method for contrast enhanced lymphography using the foregoing contrast agent, and a method for diagnosis of lymph node cancers using the foregoing contrast agent. Using such a mussel adhesive protein-mimetic copolymer, the surface of iron oxide is modified and dispersed well in water to prepare a colloidal solution, which in turn forms the contrast agent containing the colloidal solution. The inventive contrast agent does not have toxicity and is easily taken up to the lymph node to exhibit excellent contrast imaging effects. The contrast agent of the present invention is useful for diagnosis of metastatic cancers.