cis-3,4-Tetramethylen-azetidinon-(2) | 874292-57-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: cis-3,4-Tetramethylen-azetidinon-(2)
• 英文别名: (1R,6S)-7-azabicyclo[4.2.0]octan-8-one；cis-7-Azabicyclo[4.2.0]octan-8-one
• CAS: 874292-57-6
• 化学式: C₇H₁₁NO
• 分子量: 125.17
• InChiKey: SQHJLZVUXVHXKC-RITPCOANSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  cis-3,4-Tetramethylen-azetidinon-(2) 生成 (1S,6R)-7-amino-7-azabicyclo[4.2.0]octan-8-one
  参考文献：
  名称：

  JOHNSON P. Y.; HATCH III C. E.; SCHMUFF N. R., J. CHEM. SOC. CHEM. COMMUNS , 1975, NO 17, 725-726

  摘要：

  DOI：
• 作为产物：
  描述：

  7-hydroxymethyl-7-azabicyclo[4.2.0]octan-8-one 在 ammonium hydroxide 作用下， 以 甲醇 、 水 、 丙酮 为溶剂， 反应 22.0h， 生成 cis-3,4-Tetramethylen-azetidinon-(2)
  参考文献：
  名称：

  Hairpin Folding Behavior of Mixed α/β-Peptides in Aqueous Solution

  摘要：

  The invention of new strategies for the design of protein-mimetic oligomers that manifest the folding encoded in natural amino acid sequences is a significant challenge. In contrast to the a-helix, mimicry of protein beta-sheets is less understood. We report here the aqueous folding behavior of a prototype alpha-peptide hairpin model sequence varied at cross-strand positions by incorporation of 16 different beta-amino acid monomers. Our results provide a folding propensity scale for beta-residues in a protein beta-sheet context as well as high-resolution structures of several mixed-backbone alpha/beta-peptide hairpins in water.

  DOI：

  10.1021/ja2002346

文献信息

• Antimicrobial N-acyl-2-azetidinones
  申请人：THE UPJOHN COMPANY

  公开号：EP0232017A1

  公开（公告）日：1987-08-12

  The present invention provides novel compositions of matter and processes for their preparation. Particularly, the present invention relates to novel monocyclic β-lactams of formula I, having a carbonyl group, other than a negatively charged group, attached to the N-1 position. The compounds are useful as antimicrobial agents or as intermediates thereto. The present invention also provides a novel process for making these compounds which utilizes palladium (O)-­catalyzed carbonylation of an appropriate 2-bromo-1-propen-3-yl amine and novel intermediates prepared by this process.

  本发明提供了一种新的物质组合物及其制备过程。特别是，本发明涉及一类新型的单环β-内酰胺类化合物，其具有一个羰基团，而不是一个负电荷团，连接到N-1位置。这些化合物可用作抗菌剂或作为其前体。本发明还提供了一种制造这些化合物的新过程，该过程使用钯(0)催化的2-溴-1-丙烯-3-基胺的羰基化反应，以及通过该过程制备的新型中间体。
• [EN] PYRIDIN-2 (1H) -ONE DERIVATIVES USEFUL AS MEDICAMENTS FOR THE TREATMENT OF MYELOPROLIFERATIVE DISORDERS, TRANSPLANT REJECTION, IMMUNE-MEDIATED AND INFLAMMATORY DISEASES<br/>[FR] DÉRIVÉS DE PYRIDIN-2(1H)-ONE UTILES EN TANT QUE MÉDICAMENTS POUR LE TRAITEMENT DE TROUBLES MYÉLOPROLIFÉRATIFS, DU REJET DE GREFFE, DE MALADIES À MÉDIATION IMMUNITAIRE ET INFLAMMATOIRES
  申请人：ALMIRALL SA

  公开号：WO2012160030A1

  公开（公告）日：2012-11-29

  Compoundshaving the chemical structure of formula (I) are disclosed; as well as process for theirpreparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).

  揭示了具有化学结构的化合物（I）的公式；以及它们的制备过程，包括它们的药物组合物和它们作为Janus激酶（JAK）抑制剂在治疗中的用途。
• PYRIDIN-2(1H)-ONE DERIVATIVES USEFUL AS MEDICAMENTS FOR THE TREATMENT OF MYELOPROLIFERATIVE DISORDERS, TRANSPLANT REJECTION, IMMUNE-MEDIATED AND INFLAMMATORY DISEASES
  申请人：Eastwood Paul Robert

  公开号：US20140170110A1

  公开（公告）日：2014-06-19

  Compounds having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).

  公开了具有化学式（I）的化合物；以及它们的制备方法、包含它们的制药组合物以及它们作为Janus激酶（JAK）抑制剂在治疗中的用途。
• BERNATH G.; TOTH G.; FUELOEP F.; GOENDOES G.; GERA L., MAGY. KEM. FOLYOIRAT., 1980, 86, NO 5, 232-237
  作者：BERNATH G.、 TOTH G.、 FUELOEP F.、 GOENDOES G.、 GERA L.

  DOI：——

  日期：——
• STAJER, GEZA;SZOKE-MOLNAR, ZSOLT;BERNATH, GABOR;SOHAR, PAL, TETRAHEDRON, 46,(1990) N, C. 1943-1950
  作者：STAJER, GEZA、SZOKE-MOLNAR, ZSOLT、BERNATH, GABOR、SOHAR, PAL

  DOI：——

  日期：——