(6-amino-5-((2,6-dichIoro-3-fluorophenyl)ethoxy)pyridazin-3-yl)-N-(4-(morpholin-4-yl)phenyl)carboxamide | 1201916-51-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: (6-amino-5-((2,6-dichIoro-3-fluorophenyl)ethoxy)pyridazin-3-yl)-N-(4-(morpholin-4-yl)phenyl)carboxamide
• 英文别名: 6-amino-5-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-N-(4-morpholin-4-ylphenyl)pyridazine-3-carboxamide
• CAS: 1201916-51-9
• 化学式: C₂₃H₂₂Cl₂FN₅O₃
• 分子量: 506.364
• InChiKey: AINZMZNXSCOJRF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  34
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  103
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• SUBSTITUTED PYRIDAZINE CARBOXAMIDE COMPOUNDS
  申请人：Liang Congxin

  公开号：US20130190298A1

  公开（公告）日：2013-07-25

  The new pyridazine derivatives have unexpected drug properties as inhibitors of protein kinases especially against ALK and are useful in treating disorders related to abnormal protein kinase activities such as cancer, neurological and psychiatric diseases.

  新的吡啶嗪衍生物具有意想不到的药物特性，作为蛋白激酶抑制剂，尤其对ALK具有作用，并且在治疗与异常蛋白激酶活性相关的疾病，如癌症、神经和精神疾病方面是有用的。
• SUBSTITUTUTED 6-AMINO-PYRIDAZIN-3-YL-CARBOXAMIDE COMPOUNDS AS PROTEIN KINASE MODULATORS
  申请人：Xcovery Holding Company LLC

  公开号：EP2625176B1

  公开（公告）日：2016-08-17
• SUBSTITUTED PYRIDAZINE CARBOXAMIDE COMPOUNDS AS KINASE INHIBITOR COMPOUNDS
  申请人：Liang Congxin

  公开号：US20110160209A1

  公开（公告）日：2011-06-30

  Pyridazine derivatives have unexpected drug properties as inhibitors of protein kinases and are useful in treating disorders related to abnormal protein kinase activities such as cancer.
• SUBSTITUTED PYRIDAZINE CARBOXIMIDE COMPOUNDS
  申请人：Xcovery Holding Company, LLC

  公开号：US20160068493A1

  公开（公告）日：2016-03-10

  The new pyridazine derivatives have unexpected drug properties as inhibitors of protein kinases especially against ALK and are useful in treating disorders related to abnormal protein kinase activities such as cancer, neurological and psychiatric diseases.
• US9126947B2
  申请人：——

  公开号：US9126947B2

  公开（公告）日：2015-09-08