(S)-6-[(1E,3Z)-(R)-3-Ethyl-7-(4-methoxy-benzyloxy)-5-methyl-hepta-1,3-dienyl]-5,6-dihydro-pyran-2-one | 320740-07-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (S)-6-[(1E,3Z)-(R)-3-Ethyl-7-(4-methoxy-benzyloxy)-5-methyl-hepta-1,3-dienyl]-5,6-dihydro-pyran-2-one
• CAS: 320740-07-6
• 化学式: C₂₃H₃₀O₄
• 分子量: 370.489
• InChiKey: ZTHJDDMOVHUYIK-FIHWHTHRSA-N

反应信息

• 作为反应物：
  描述：

  (S)-6-[(1E,3Z)-(R)-3-Ethyl-7-(4-methoxy-benzyloxy)-5-methyl-hepta-1,3-dienyl]-5,6-dihydro-pyran-2-one 在 pH 6.9 phosphate buffer 、 戴斯-马丁氧化剂 、 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 二氯甲烷 、 叔丁醇 为溶剂， 反应 1.0h， 生成 (4Z,6E)-(R)-5-Ethyl-3-methyl-7-((S)-6-oxo-3,6-dihydro-2H-pyran-2-yl)-hepta-4,6-dienal
  参考文献：
  名称：

  Participation of the conjugated diene part for potent cytotoxicity of callystatin A, a spongean polyketide

  摘要：

  5-epi, 10-epi, 8-Deethyl, and 10-demethyl analogues of callystatin A, a potent cytotoxic spongean polyketide, were synthesized to elucidate structure-requirement for cytotoxic potency. Inversion of the asymmetric center at C-10 in callystatin A minimally affected the activity, while lack of the 10-methyl group in callystatin A decreased cytotoxicity. In addition, the C-5 epimer and the 8-deethyl analogue of callystatin A showed weaker cytotoxicity. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(00)00199-1
• 作为产物：
  描述：

  (S)-2-[(1E,3Z)-(R)-3-Ethyl-7-(4-methoxy-benzyloxy)-5-methyl-hepta-1,3-dienyl]-6-isopropoxy-3,6-dihydro-2H-pyran 在 Celite 、 Dowex HCR-W₂ (H⁺ form) 、 silver carbonate 作用下， 以 水 、 丙酮 、 苯 为溶剂， 反应 11.0h， 生成 (S)-6-[(1E,3Z)-(R)-3-Ethyl-7-(4-methoxy-benzyloxy)-5-methyl-hepta-1,3-dienyl]-5,6-dihydro-pyran-2-one
  参考文献：
  名称：

  Participation of the conjugated diene part for potent cytotoxicity of callystatin A, a spongean polyketide

  摘要：

  5-epi, 10-epi, 8-Deethyl, and 10-demethyl analogues of callystatin A, a potent cytotoxic spongean polyketide, were synthesized to elucidate structure-requirement for cytotoxic potency. Inversion of the asymmetric center at C-10 in callystatin A minimally affected the activity, while lack of the 10-methyl group in callystatin A decreased cytotoxicity. In addition, the C-5 epimer and the 8-deethyl analogue of callystatin A showed weaker cytotoxicity. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(00)00199-1