(12Z,23R,73S,82Z)-11H,81H-1,2,8(3,1),7(1,3)-tetraindolinacyclododecaphane-22,72-dione | 1356833-16-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯啉
• 英文名称: (12Z,23R,73S,82Z)-11H,81H-1,2,8(3,1),7(1,3)-tetraindolinacyclododecaphane-22,72-dione
• CAS: 1356833-16-3
• 化学式: C₄₀H₃₆N₄O₂
• 分子量: 604.751
• InChiKey: RJKGFLLSZJJLFH-MAZIBIHTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.83
• 重原子数：
  46.0
• 可旋转键数：
  0.0
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  50.48
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  1-(4-吲哚-1-基丁基)吲哚 、 3-Diazonio-1-[4-(3-diazonio-2-oxidoindol-1-yl)butyl]indol-2-olate 在 dirhodium tetraacetate 作用下， 以 二氯甲烷 为溶剂， 反应 0.75h， 生成 (12Z,23R,73S,82Z)-11H,81H-1,2,8(3,1),7(1,3)-tetraindolinacyclododecaphane-22,72-dione 、 (1S,22S)-9,14,29,34-tetrazanonacyclo[32.6.1.12,9.114,21.122,29.03,8.015,20.023,28.035,40]tetratetraconta-2(44),3,5,7,15,17,19,21(43),23,25,27,35,37,39-tetradecaene-41,42-dione
  参考文献：
  名称：

  Rhodium(II) catalyzed intermolecular double C-alkylation: a method for the synthesis of tetraindoles and indolophanes

  摘要：

  Double C-alkylation of cyclic diazoamides or bis-diazoamides with indoles or bis-indoles has been achieved to synthesize tetraindole derivatives using rhodium(II) acetate as a catalyst under mild reaction conditions with complete regioselectivity. The intermolecular double C-alkylation reaction strategy was successfully applied to synthesize indolophanes in moderate yield with excellent regiocontrol. The structure and stereochemistry of macrocycles were unequivocally confirmed with the help of single-crystal X-ray structure analyses. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.11.073