Barbital hydrochloride | 23851-27-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: Barbital hydrochloride
• 英文别名: 5,5-diethyl-1,3-diazinane-2,4,6-trione;hydrochloride
• CAS: 23851-27-6
• 化学式: C8H13ClN2O3
• 分子量: 220.65
• InChiKey: SACKVYGWWZDWQS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.58
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  75.3
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• Process for producing physiologically active substance by multienzyme process and apparatus for the same
  申请人：Imahori, Kazutomo

  公开号：EP0084975A2

  公开（公告）日：1983-08-03

  A process for converting AMP into ATP which comprises (a) using an enzyme which converts AMP into ADP and has been produced from microorganisms having an optimum growth temperature of 50°C to 85°C and an enzyme which converts ADP into ATP and has been produced from microorganisms having an optimum growth temperature of 50° C to 85°C and an apparatus for the same are disclosed. In addition, there is disclosed a process for producing a physiologically active substance by a multienzyme process which comprises forming ATP from AMP by the step (a), (b) syntherizing a physiologically active substance with the resulting ATP, converting AMP resulting from the reaction in step (b) into ATP by the reaction in step (a), and repeatedly utilizing the converted ATP for synthesis of the physiologically active substance in step (b). By using the process it is possible to stably and efficiently carry out conversion of AMP into ATP over a long period time. Further, it is possible to carry out continuously and economically an enzymic reaction using ATP as an auxiliary factor with very good efficiency. Whereby it has become possible to practically operate the so-called bioreactor wherein synthetic reactions in the living body are carried out as industrial chemical reactions outside the living body.

  本发明公开了一种将 AMP 转化为 ATP 的工艺，该工艺包括(a)使用一种将 AMP 转化为 ADP 的酶，该酶由最适生长温度为 50℃至 85℃的微生物产生；以及一种将 ADP 转化为 ATP 的酶，该酶由最适生长温度为 50℃至 85℃的微生物产生。此外，还公开了一种通过多酶工艺生产生理活性物质的工艺，该工艺包括步骤(a)由 AMP 生成 ATP，(b)用生成的 ATP 合成生理活性物质，步骤(b)中反应生成的 AMP 通过步骤(a)中的反应转化为 ATP，以及重复利用转化的 ATP 合成步骤(b)中的生理活性物质。通过使用该工艺，可以长期稳定、高效地将 AMP 转化为 ATP。此外，还可以利用 ATP 作为辅助因素，持续、经济、高效地进行酶促反应。这样，所谓的生物反应器就有了实际操作的可能性，在生物体内的合成反应就像在生物体外进行的工业化学反应一样。
• Nonspecific adsorption-free method for assaying antibody and assay reagent
  申请人：Eisai Co., Ltd.

  公开号：EP0416466A1

  公开（公告）日：1991-03-13

  The assay method comprises the steps of adding a serum specimen to a solid phase at a pH value of 9 to 10 and assaying an antibody in the specimen. The antibody may be adult T cell leukemia virus antibody (HTLV-I antibody).

  化验方法包括以下步骤：将血清样本加入 pH 值为 9 至 10 的固相中，并化验样本中的抗体。抗体可以是成人 T 细胞白血病病毒抗体（HTLV-I 抗体）。
• Modified proenzymes as substrates for proteolytic enzymes
  申请人：NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO

  公开号：EP0691409A1

  公开（公告）日：1996-01-10

  Detection or determination of a protease in a sample by incubating the sample with a substrate of the protease and observing proteolytic cleavage of said substrate. The substrate is a modified proenzyme containing a recognition site, e.g., an activation site, cleavable by said protease. Proteolytic cleavage of the modified proenzyme is detected by observing the resulting activity using a suitable substrate of the activated proenzyme. The protease may be e.g. an aspartic protease or a metalloprotease, and the modified proenzyme e.g. pro-urokinase having a mutant activation site which is cleavable by the protease to be determined.

  通过将样品与蛋白酶的底物孵育，并观察所述底物的蛋白水解裂解情况，检测或确定样品中的蛋白酶。底物是含有可被蛋白酶裂解的识别位点（如活化位点）的修饰原酶。通过使用活化原酶的合适底物观察由此产生的活性，检测修饰原酶的蛋白水解裂解。蛋白酶可以是天冬氨酸蛋白酶或金属蛋白酶，经修饰的原酶可以是具有可被待定蛋白酶裂解的突变活化位点的原尿激酶。
• US4882276A
  申请人：——

  公开号：US4882276A

  公开（公告）日：1989-11-21
• US4960696A
  申请人：——

  公开号：US4960696A

  公开（公告）日：1990-10-02