(S)-4,4-Dimethyl-1-phenyl-pentan-2-ol | 955997-28-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (S)-4,4-Dimethyl-1-phenyl-pentan-2-ol
• 英文别名: (I+/-S)-I+/--(2,2-Dimethylpropyl)benzeneethanol；(2S)-4,4-dimethyl-1-phenylpentan-2-ol
• CAS: 955997-28-1
• 化学式: C₁₃H₂₀O
• 分子量: 192.301
• InChiKey: MBRZYUHBFJXHNF-GFCCVEGCSA-N

反应信息

• 作为产物：
  描述：

  magnesium,2-methylpropane,bromide 、 (E)-3-((4R,8R)-6-Benzyl-4,8-diphenyl-[1,3,6,2]dioxazaborocan-2-yl)-acrylic acid benzyl ester 在 copper(l) iodide 、 sodium perborate 作用下， 以 乙醚 、 四氢呋喃 、 水 为溶剂， 生成 (S)-4,4-Dimethyl-1-phenyl-pentan-2-ol 、 (R)-4,4-Dimethyl-1-phenyl-pentan-2-ol
  参考文献：
  名称：

  Chiral vinyl dioxazaborocines in synthesis: asymmetric cuprate additions to β-boronyl acrylates and vinyl sulfones

  摘要：

  The first examples of the addition of organometallic reagents to electron deficient boron-substituted olefins are reported. Thus, copper catalysed addition of Grignard reagents to chiral acryloyl and vinylsulfonyl dioxazaborocines, followed by oxidative removal of the boron, gives beta-hydroxy esters and sulfones with asymmetric inductions up to 81 and 95% ee, respectively. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)00572-4