| 1480545-12-7

• 分子结构分类: 有机化合物 - 有机硫化合物 - 异硫氰酸盐
• CAS: 1480545-12-7
• 化学式: C₆H₇NOS
• 分子量: 141.194
• InChiKey: SIHFEJIXIOFYNK-UHFFFAOYSA-N

物化性质

• 沸点：
  246.2±20.0 °C(Predicted)
• 密度：
  0.95±0.1 g/cm3(Predicted)

反应信息

• 作为反应物：
  描述：

  、 在 copper diacetate 、 sodium ascorbate 作用下， 以 四氢呋喃 、 甲醇 、 水 为溶剂， 生成
  参考文献：
  名称：

  Synthesis of Multifunctional PAMAM–Aminoglycoside Conjugates with Enhanced Transfection Efficiency

  摘要：

  The development of multifunctional vectors for efficient and safe gene delivery is one of the major challenges for scientists working in the gene therapy field. In this context, we have designed a novel type of aminoglycoside-rich dendrimers with a defined structure based on polyamidoamine (PAMAM) in order to develop efficient, nontoxic gene delivery vehicles. Three different conjugates, i.e., PAMAM G4-neamine, -paromomycin, and -neomycin, were synthesized and characterized by nuclear magnetic resonance (NMR) and MALDI analysis. The conjugates were found to self-assemble electrostatically with plasmid DNA, and unlike neamine conjugate, each at its optimum showed increased gene delivery potency compared to PAMAM G4 dendrimer in three different cell lines, along with negligible cytotoxicity. These results all disclosed aminoglycosides as suitable functionalities for tailoring safe and efficient multifunctional gene delivery vectors.

  DOI：

  10.1021/bc4003635