5-chloro-thiophene-2-carboxylic acid {4-methyl-3-[2-(pyridin-4-ylamino)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-phenyl}-amide | 1332327-98-6

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: 5-chloro-thiophene-2-carboxylic acid {4-methyl-3-[2-(pyridin-4-ylamino)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-phenyl}-amide
• 英文别名: 5-chloro-N-[4-methyl-3-[2-(pyridin-4-ylamino)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]phenyl]thiophene-2-carboxamide
• CAS: 1332327-98-6
• 化学式: C₂₄H₂₁ClN₆OS
• 分子量: 476.989
• InChiKey: UYVWYVONEXQICW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  33
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  111
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• [EN] BICYCLIC COMPOUNDS AND THEIR USES AS DUAL C-SRC / JAK INHIBITORS<br/>[FR] COMPOSÉS BICYCLIQUES ET UTILISATIONS ASSOCIÉES EN TANT QU'INHIBITEURS MIXTES DE C-SRC/JAK
  申请人：DEBIOPHARM SA

  公开号：WO2011101806A1

  公开（公告）日：2011-08-25

  The present invention relates to substituted aromatic bicyclic compounds containing pyrimidine and pyridine rings of formula (I) having the structure as well as pharmaceutically acceptable salts thereof. The compounds of the present invention are useful as tyrosine kinase inhibitors, preferably SRC family kinases (SFKs) inhibitors, in particular as multi SFK/JAK. kinases inhibitors and even preferably as dual c-SRC/JAK kinases inhibitors, thereby inhibiting the STAT3 activation and therefore abnormal growth of particular cell types. Notably, the compounds of the present invention are useful for the treatment or inhibition of certain diseases that are the result of deregulation of STAT3.

  本发明涉及含有嘧啶和吡啶环的取代芳香族双环化合物的化学式(I)，以及其药学上可接受的盐。本发明的化合物可用作酪氨酸激酶抑制剂，优选为SRC家族激酶（SFKs）抑制剂，特别是作为多种SFK/JAK激酶抑制剂，甚至更优选地作为双重c-SRC/JAK激酶抑制剂，从而抑制STAT3的激活，进而抑制特定细胞类型的异常生长。值得注意的是，本发明的化合物可用于治疗或抑制由于STAT3失调而导致的某些疾病。
• BICYCLIC COMPOUNDS AND THEIR USES AS DUAL C-SRC / JAK INHIBITORS
  申请人：Mc Allister Andrès

  公开号：US20130143895A1

  公开（公告）日：2013-06-06

  The present invention relates to substituted aromatic bicyclic compounds containing pyrimidine and pyridine rings of formula (I) having the structure as well as pharmaceutically acceptable salts thereof. The compounds of the present invention are useful as tyrosine kinase inhibitors, preferably SRC family kinases (SFKs) inhibitors, in particular as multi SFK/JAK. kinases inhibitors and even preferably as dual c-SRC/JAK kinases inhibitors, thereby inhibiting the STAT3 activation and therefore abnormal growth of particular cell types. Notably, the compounds of the present invention are useful for the treatment or inhibition of certain diseases that are the result of deregulation of STAT3.

  本发明涉及公式（I）的含有嘧啶和吡啶环的取代芳香族双环化合物及其药学上可接受的盐。本发明的化合物可用作酪氨酸激酶抑制剂，优选为SRC家族激酶（SFKs）抑制剂，特别是作为多种SFK/JAK激酶抑制剂，更优选作为双重c-SRC/JAK激酶抑制剂，从而抑制STAT3的活化，因此抑制特定细胞类型的异常生长。值得注意的是，本发明的化合物可用于治疗或抑制由STAT3失调引起的某些疾病。
• US8440679B2
  申请人：——

  公开号：US8440679B2

  公开（公告）日：2013-05-14
• US8962637B2
  申请人：——

  公开号：US8962637B2

  公开（公告）日：2015-02-24