2-Hydroxymethyl-2-p-toluolsulfonamidopropan-1,3-diol | 92100-12-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Hydroxymethyl-2-p-toluolsulfonamidopropan-1,3-diol
• 英文别名: N-(1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl)-4-methylbenzenesulfonamide；N-[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]-4-methylbenzenesulfonamide
• CAS: 92100-12-4
• 化学式: C₁₁H₁₇NO₅S
• mdl: MFCD04000553
• 分子量: 275.326
• InChiKey: KCDXWHWSNJHPPY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.454
• 拓扑面积：
  115
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  对甲苯磺酰氯 、 三羟甲基氨基甲烷 在 potassium carbonate 作用下， 以 异丙醇 为溶剂， 生成 2-Hydroxymethyl-2-p-toluolsulfonamidopropan-1,3-diol
  参考文献：
  名称：

  Hypoglycaemic Agents. Part III

  摘要：

  描述了托布唑胺的新变体。

  DOI：

  10.1111/j.2042-7158.1962.tb11132.x

文献信息

• Topical formulation and method for preventing or treating acne
  申请人：Wu Lester J.

  公开号：US10548862B2

  公开（公告）日：2020-02-04

  Provided is a topical formulation for preventing or treating acne, including a benzenesulfonamide derivative, and a pharmaceutically or cosmetically acceptable excipient. Also provided is a method for preventing or treating acne, including applying the topical formulation on skin of a subject in need thereof.

  本发明提供了一种用于预防或治疗痤疮的外用制剂，包括一种苯磺酰胺衍生物和一种药学上或化妆品上可接受的赋形剂。还提供了一种预防或治疗痤疮的方法，包括在有需要的受试者皮肤上使用该外用制剂。
• NOVEL PHARMACEUTICAL COMPOSITIONS OF BENZENESULFONAMIDE DERIVATIVES FOR TREATMENT OF ADENOID CYSTIC CARCINOMA
  申请人：GONGWIN BIOPHARM HOLDINGS CO., LTD.

  公开号：US20170172951A1

  公开（公告）日：2017-06-22

  Provided is a method for treating adenoid cystic carcinoma by using a pharmaceutical composition including benzenesulfonamide derivatives and pharmaceutically acceptable carriers.
• TOPICAL FORMULATION AND METHOD FOR PREVENTING OR TREATING ACNE
  申请人：Wu Lester J.

  公开号：US20190201356A1

  公开（公告）日：2019-07-04

  Provided is a topical formulation for preventing or treating acne, including a benzenesulfonamide derivative, and a pharmaceutically or cosmetically acceptable excipient. Also provided is a method for preventing or treating acne, including applying the topical formulation on skin of a subject in need thereof.
• BENZENESULFONAMIDE DERIVATIVES AND METHOD FOR TREATING CANCER
  申请人：GONGWIN BIOPHARM HOLDINGS CO., LTD.

  公开号：US20190321313A1

  公开（公告）日：2019-10-24

  Provided are benzenesulfonamide derivatives or pharmaceutically acceptable salts thereof. Also provided is a method for treating cancer by using a pharmaceutical composition including the benzenesulfonamide derivatives or pharmaceutically acceptable salts thereof and pharmaceutically acceptable carriers.
• BENZENESULFONAMIDE DERIVATIVES AND METHOD FOR MODULATING LIPID RAFT
  申请人：Gongwin Biopharm Co., Ltd.

  公开号：US20200338028A1

  公开（公告）日：2020-10-29

  The present disclosure relates to a benzenesulfonamide derivative which is useful to modulate lipid raft integrity of cancer cells and the use of the benzenesulfonamide derivative in prevention or treatment of diseases or conditions which can be ameliorated by change of the lipid raft integrity in a subject.