2-Amino-1,1-bis-(2-methoxy-phenyl)-4-methyl-pentan-1-ol | 54464-15-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-Amino-1,1-bis-(2-methoxy-phenyl)-4-methyl-pentan-1-ol
• 英文别名: 2-Amino-1,1-bis(2-methoxyphenyl)-4-methylpentan-1-ol
• CAS: 54464-15-2
• 化学式: C₂₀H₂₇NO₃
• 分子量: 329.439
• InChiKey: ITGIXPAUSQUYGM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  64.7
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Process for producing optically active amines
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0485069A1

  公开（公告）日：1992-05-13

  Disclosed is a process for producing an optically active amine represented by the formula (IV) wherein R₇ and R₈ each independently denote an alkyl group, aryl group or aralkyl group which said alkyl, aryl or aralky group is optionally substitued, providing that they do not denote the same specific group at the same time, and * indicates an asymmetric carbon atom, which comprises reacting an asymmetric reducing agent obtained from (1) an optically active amine derivative represented by the formula (I) wherein R₁ denotes an alkyl group, aryl group, or aralkyl group; R₂ denotes a hydrogen atom, alkyl group or aralkyl group; R₃ denotes an alkyl group, an aryl group which said alkyl or aryl group is optionally substituted, or a substituent represented by the formula (II) wherein R₄ and R₅ each independently denote a hydrogen atom, alkyl group, aryl group or aralkyl group which said alkyl, aryl or aralkyl group is optionally substituted and * is a defined above, (2) a metal borohydride and (3) sulfuric acid, with either the syn-isomer or the anti-isomer of an oxime derivative represented by the formula (III) or with a mixture rich in either one of the two isomers wherein R₆ denotes an alkyl group, aralkyl group or alkyl-substituted silyl group, and R₇ and R₈ are as defined above. The optically active amine obtained can be used as a resolving agent for preparing medicinal agents, agricultural chemicals, or intermediates thereof.

  本发明公开了一种由式（IV）表示的光学活性胺的生产工艺 其中，R₇ 和 R₈ 各自独立地表示烷基、芳基或芳烷基，所述烷基、芳基或芳烷基可任选地被取代，但它们不能同时表示相同的特定基团，且 * 表示不对称碳原子，该工艺包括使由 (1) 式 (I) 所代表的光学活性胺衍生物得到的不对称还原剂进行反应 其中 R₁ 表示烷基、芳基或芳烷基；R₂ 表示氢原子、烷基或芳烷基；R₃ 表示烷基、芳基（所述烷基或芳基被任选取代）或式 (II) 所代表的取代基 其中，R₄ 和 R₅ 各自独立地表示氢原子、烷基、芳基或芳烷基，其中所述烷基、芳基或芳烷基任选被取代，且 * 如上定义；(2) 金属硼氢化物；(3) 硫酸、 与式 (III) 所代表的肟衍生物的同分异构体或反异构体，或与富含这两种异构体中任何一种的混合物混合 其中 R₆ 表示烷基、芳烷基或烷基取代的硅烷基，R₇ 和 R₈ 如上定义。 得到的光学活性胺可用作制备药剂、农药或其中间体的溶解剂。
• Transition metal compounds, catalyst components and catalysts for olefin polymerization, and process for producing olefinic polymers
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP0942010A1

  公开（公告）日：1999-09-15

  A transition metal compound represented by the general formula (2) or (3) described below, a catalyst component for olefin polymerization comprising said transition metal compound, a catalyst component for olefin polymerization using said transition metal compound and (C) and/or (D) described below, and a process for producing an olefinic polymer wherein olefins are homopolymerized or olefins are copolymerized with other olefins and/or other polymerizable unsaturated compound using said catalyst for olefin polymerization. (C): A specific aluminum compound (D): A specific boron compound

  一种由下述通式(2)或(3)表示的过渡金属化合物，一种包含所述过渡金属化合物的烯烃聚合催化剂组分，一种使用所述过渡金属化合物和下述(C)和/或(D)的烯烃聚合催化剂组分，以及一种生产烯烃聚合物的工艺，其中使用所述烯烃聚合催化剂使烯烃均聚或使烯烃与其他烯烃和/或其他可聚合的不饱和化合物共聚。 (C):一种特定的铝化合物 (D)：一种特定的硼化合物
• METHOD FOR PRODUCING OPTICALLY ACTIVE BISAMIDO ALCOHOL COMPOUND
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP1698616A1

  公开（公告）日：2006-09-06

  It is provided that a method for producing an optically active bisamidoalcohol compound represented by the formula (3): wherein R1 represents a C1-6 alkyl group, an optionally substituted phenyl group, an optionally substituted aralkyl group or a hydrogen atom, or two R1s, which are bonded to the same carbon atom, are bonded to form a ring together with the carbon atom to which they are bonded, R2 represents a C1-6 alkyl group, an optionally substituted phenyl group, a 1-naphthyl group, a 2-naphthyl group or an optionally substituted aralkyl group, R3 and R4 are the same or different, and each represents a hydrogen atom or C1-3 alkyl group, m represents an integer of 0 to 2, and * represents an asymmetric center, which comprises reacting an optically active aminoalcohol compound represented by the formula (1): wherein R1, R2 and * are as defined above, with a diester compound represented by the formula (2): wherein R3, R4 and m are as defined above and R5 represents a C1-3 alkyl group, in the presence of a lithium compound.

  本发明提供了一种生产由式（3）代表的光学活性双氨基醇化合物的方法： 其中 R1 代表 C1-6 烷基、任选取代的苯基、任选取代的芳烷基或氢原子，或两个 R1 与同一碳原子键合，与其键合的碳原子一起形成环、 R2 代表 C1-6 烷基、任选取代的苯基、1-萘基、2-萘基或任选取代的芳基、 R3 和 R4 相同或不同，各自代表氢原子或 C1-3 烷基、 m 代表 0 至 2 的整数，以及 * 代表不对称中心，其中包括与由式（1）代表的光学活性氨基醇化合物反应： 其中 R1、R2 和 * 如上定义、 与式 (2) 所代表的二酯化合物反应： 其中 R3、R4 和 m 如上定义，R5 代表 C1-3 烷基、 在锂化合物存在下。
• METHOD FOR PRODUCING OPTICALLY ACTIVE CYCLOALKYLIDENE BISOXAZOLINE COMPOUND AND INTERMEDIATE THEREOF
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP1698617A1

  公开（公告）日：2006-09-06

  It is provided to an optically active cycloalkylidenebisamidoalcohol compound represented by the formula (3): wherein R1 represents a C1-6 alkyl group, an optionally substituted phenyl group, an optionally substituted aralkyl group or a hydrogen atom, or two R1s, which are bonded to the same carbon atom, are bonded to form a ring together with the carbon atom to which they are bonded, R2 represents a C1-6 alkyl group, an optionally substituted aralkyl group or an optionally substituted phenyl group and * represents an asymmetric center, a method for producing it and a method for producing an optically active cycloalkylidenebisoxazoline compound represented by the formula (4): wherein R1, R2 and * are as defined above, using thereof.

  提供了一种由式（3）代表的具有光学活性的环烷基亚氨基双酰胺醇化合物： 其中R1代表C1-6烷基、任选取代的苯基、任选取代的芳烷基或氢原子，或两个R1，它们键合到同一个碳原子上，与它们所键合的碳原子一起形成一个环，R2代表C1-6烷基、任选取代的芳烷基或任选取代的苯基，*代表一个不对称中心，还提供了一种生产该化合物的方法和一种生产由式(4)表示的光学活性环烷亚基双噁唑啉化合物的方法： 其中 R1、R2 和 * 如上文所定义，使用它们。
• Transition metal compound, catalyst component for olefin polymerization, catalyst for olefin polymerization, and process for producing olefinic polymer
  申请人：——

  公开号：US20010027162A1

  公开（公告）日：2001-10-04

  A transition metal compound represented by the general formula (2) or (3) described below, a catalyst component for olefin polymerization comprising said transition metal compound, a catalyst component for olefin polymerization using said transition metal compound and (C) and/or (D) described below, and a process for producing an olefinic polymer wherein olefins are homopolymerized or olefins are copolymerized with other olefins and/or other polymerizable unsaturated compound using said catalyst for olefin polymerization. 1 (C); A specific aluminum compound (D); A specific boron compound

  一种由下述通式(2)或(3)表示的过渡金属化合物，一种包含所述过渡金属化合物的烯烃聚合催化剂组分，一种使用所述过渡金属化合物和下述(C)和/或(D)的烯烃聚合催化剂组分，以及一种生产烯烃聚合物的工艺，其中使用所述烯烃聚合催化剂使烯烃均聚或使烯烃与其他烯烃和/或其他可聚合的不饱和化合物共聚。 1 (C); 一种特定的铝化合物 (D) 一种特定的硼化合物