(RS)-(4-carbamimidoyl-phenylamino)-[5-ethoxy-2-fluoro-3-(1-methyl-piperidin-4-yloxy)-phenyl]-acetic acid | 577794-17-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (RS)-(4-carbamimidoyl-phenylamino)-[5-ethoxy-2-fluoro-3-(1-methyl-piperidin-4-yloxy)-phenyl]-acetic acid
• 英文别名: 2-(4-Carbamimidoylanilino)-2-[5-ethoxy-2-fluoro-3-(1-methylpiperidin-4-yl)oxyphenyl]acetic acid
• CAS: 577794-17-3
• 化学式: C₂₃H₂₉FN₄O₄
• 分子量: 444.506
• InChiKey: UJHGDHHSUXVKDH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  32
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  121
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• N-(4-CARBAMIMIDOYL-PHENYL)-GLYCINE DERIVATIVES
  申请人：——

  公开号：US20030166683A1

  公开（公告）日：2003-09-04

  The invention is concerned with water soluble N—(4-carbamimidoyl-phenyl)-glycine derivatives of formula (I) 1 wherein R 1 to R 4 and n are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit the formation of coagulation factors Xa, IXa and thrombin induced by factor VIIa and tissue factor and can be used as medicaments.

  本发明涉及水溶性的公式(I)1中的N-(4-氨基甲酰基苯基)甘氨酸衍生物，其中R1至R4和n如说明和权利要求中所定义，以及其生理上可接受的盐。这些化合物能抑制由因子VIIa和组织因子诱导的凝血因子Xa、IXa和凝血酶的形成，可用作药物。
• WATER SOLUBLE PHENYLGLYCINE DERIVATIVES
  申请人：F. Hoffmann-La Roche AG

  公开号：EP1474391A1

  公开（公告）日：2004-11-10
• US6642386B2
  申请人：——

  公开号：US6642386B2

  公开（公告）日：2003-11-04
• [EN] WATER SOLUBLE PHENYLGLYCINE DERIVATIVES<br/>[FR] DERIVES HYDROSOLUBLES DE PHENYLGLYCINE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2003066588A1

  公开（公告）日：2003-08-14

  The invention is concerned with novel water soluble N-(4-carbamimidoyl-phenyl)- glycine derivatives of Formula (I); wherein R1 to R4 and n are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit the formation of coagulation factors Xa, Ixa and thrombin induced by factor VIIa and tissue factor and can be used as medicaments.