N-[4-(4-hydroxy-4',6'-dimethyl-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl)-phenyl]-2-oxo-2-(2-phenyl-5,6,7,8-tetrahydro-indolizin-3-yl)-acetamide | 1090513-69-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: N-[4-(4-hydroxy-4',6'-dimethyl-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl)-phenyl]-2-oxo-2-(2-phenyl-5,6,7,8-tetrahydro-indolizin-3-yl)-acetamide
• 英文别名: N-[4-[1-(4,6-dimethylpyridin-2-yl)-4-hydroxypiperidin-4-yl]phenyl]-2-oxo-2-(2-phenyl-5,6,7,8-tetrahydroindolizin-3-yl)acetamide
• CAS: 1090513-69-1
• 化学式: C₃₄H₃₆N₄O₃
• 分子量: 548.685
• InChiKey: XBSUERCFBROBNJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  41
• 可旋转键数：
  6
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  87.5
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• 2-OXO-2- (2-PHENYL-5,6,7,8-TETRAHYDRO-INDOLIZIN-3-YL) -ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS ANTIFUNGAL AGENTS
  申请人：Payne Lloyd James

  公开号：US20110009390A1

  公开（公告）日：2011-01-13

  The invention provides compounds of formula (I), and pharmaceutically and agriculturally acceptable salts thereof: wherein: R1, R2, R3, R4, R5, R6, R7, R8, A1, L1 and n are as defined herein. These compounds and their pharmaceutically acceptable salts are useful in the manufacture of medicaments for use in the prevention or treatment of a fungal disease. Compounds of formula (I), and agriculturally acceptable salts thereof, may also be used as agricultural fungicides.

  该发明提供了式(I)的化合物，以及其在药学和农业上可接受的盐：其中：R1、R2、R3、R4、R5、R6、R7、R8、A1、L1和n如本文所定义。这些化合物及其药学上可接受的盐在制造用于预防或治疗真菌病的药物方面是有用的。式(I)的化合物及其在农业上可接受的盐也可用作农业杀菌剂。
• US8524705B2
  申请人：——

  公开号：US8524705B2

  公开（公告）日：2013-09-03