palmitoyl-ornithine | 133849-68-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: palmitoyl-ornithine
• 英文别名: 5-Amino-2-(hexadecanoylamino)pentanoic acid
• CAS: 133849-68-0
• 化学式: C₂₁H₄₂N₂O₃
• 分子量: 370.576
• InChiKey: RBGAPYBYKCFGJS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  26
• 可旋转键数：
  19
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  92.4
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• COSMETICS
  申请人：KYOWA HAKKO KOGYO CO., LTD.

  公开号：EP1159952A1

  公开（公告）日：2001-12-05

  The present invention relates to skin aging inhibitors and/or skin quality-improving agents comprising hydroxyproline, its N-acyl derivatives or salts thereof, and cosmetic compositions for inhibiting skin aging and/or improving skin quality comprising said skin aging inhibitors and/or skin quality-improving agents.

  本发明涉及由羟脯氨酸、其 N-酰基衍生物或其盐组成的皮肤老化抑制剂和/或皮肤质量改善剂，以及由所述皮肤老化抑制剂和/或皮肤质量改善剂组成的用于抑制皮肤老化和/或改善皮肤质量的化妆品组合物。
• Skin care product containing hydroxyproline or N-acylated hydroxyproline derivatives
  申请人：KYOWA HAKKO KOGYO CO., LTD.

  公开号：EP1166767A2

  公开（公告）日：2002-01-02

  The present invention provides cosmetics comprising (1) hydroxyproline, an N-acylated hydroxyproline derivative or a salt thereof and (2) at least one component selected from the group consisting of water-soluble vitamins, oil-soluble vitamins, high molecular peptides, high molecular polysaccharides, sphingolipids and seaweed extracts.

  本发明提供了包含以下成分的化妆品：（1）羟脯氨酸、N-酰化羟脯氨酸衍生物或其盐；（2）至少一种选自水溶性维生素、油溶性维生素、高分子肽、高分子多糖、鞘脂和海藻提取物的成分。
• SKIN TEXTURE-IMPROVING AGENTS
  申请人：KYOWA HAKKO KOGYO CO., LTD.

  公开号：EP1226809A1

  公开（公告）日：2002-07-31

  The present invention provides a skin-improving agent which comprises, as an active ingredient, proanthocyanidin in which the extent of galloylation per constitutive monomer is 10% or lower (molar ratio).

  本发明提供了一种皮肤改善剂，其有效成分包括原花青素，其中每个构成单体的五倍化程度为 10%或更低（摩尔比）。
• ANTI-AGING OR SKIN-REGENERATING COMPOSITION COMPRISING PIPERONYLIC ACID AS EFFECTIVE INGREDIENT
  申请人：Hesed Bio Co., Ltd.

  公开号：EP3662907A1

  公开（公告）日：2020-06-10

  The present invention relates to a pharmaceutical composition comprising piperonylic acid as an effective ingredient for anti-aging or regenerating the skin. A composition according to the present invention utilizes piperonylic acid that various plant species naturally contain therein and thus does not cause side effects. Piperonylic acid activates signals associated with cell survival, growth, and proliferation to exhibit the effect of increasing the resistance and survival of skin cells against external stimuli and enhancing the regeneration of the skin damaged due to external stimuli or senescence. In addition, piperonylic acid of the present invention has a similar function to EGF, but is stable and small in size in contrast to EGF. Thus, piperonylic acid of the present invention has the advantage of being able to easily move to the skin basal layer across the skin barrier and perform its function. Piperonylic acid of the present invention is expected to find applications in various fields including medicines, quasi-drugs, cosmetics, cosmetic substances, functional biomaterials, and functional food materials.

  本发明涉及一种含有胡椒酸的药物组合物，作为抗衰老或皮肤再生的有效成分。根据本发明的组合物利用了各种植物物种天然含有的胡椒酸，因此不会产生副作用。胡椒酸能激活与细胞存活、生长和增殖相关的信号，从而起到增强皮肤细胞对外界刺激的抵抗力和存活率，以及促进因外界刺激或衰老而受损的皮肤再生的作用。此外，本发明的胡椒酸具有与表皮生长因子类似的功能，但与表皮生长因子相比，胡椒酸稳定且体积小。因此，本发明的胡椒酸具有易于穿过皮肤屏障移动到皮肤基底层并发挥其功能的优点。本发明的胡椒酸有望应用于药物、准药物、化妆品、美容物质、功能性生物材料和功能性食品材料等多个领域。
• Cream-like composition
  申请人：AJINOMOTO CO., INC.

  公开号：US10736826B2

  公开（公告）日：2020-08-11

  Creamy cleansing compositions and creamy compositions which contain (A) at least one component selected from the group consisting of N-acyl acidic amino acid and a salt thereof, and N-acyl neutral amino acid and a salt thereof, (B) at least one polyhydric alcohol, (C) at least one N-mono middle-chain acyl basic amino acid or a salt thereof, and (D) water have good creamy appearance with high grade pearly gloss, are superior in form stability, and superior in the sense of use such as cream elongation, water miscibility, and the like.

  乳状清洁组合物和乳状组合物含有(A)至少一种选自 N-酰基酸性氨基酸及其盐和 N-酰基中性氨基酸及其盐组成的组的成分，(B)至少一种多元醇，(C)至少一种 N-单中链酰基碱性氨基酸或其盐，以及(D)水、(C) 至少一种 N-单中链酰基碱性氨基酸或其盐，以及 (D) 水。这些成分具有良好的奶油外观和高级珠光光泽，在形态稳定性和使用感（如奶油延展性、水混溶性等）方面都更胜一筹。