Des-cyclopropyl Saxagliptin | 841302-25-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Des-cyclopropyl Saxagliptin
• 英文别名: (2S)-1-[(2S)-2-amino-2-(3-hydroxy-1-adamantyl)acetyl]pyrrolidine-2-carbonitrile
• CAS: 841302-25-8
• 化学式: C₁₇H₂₅N₃O₂
• 分子量: 303.4
• InChiKey: OHUOCCZGTKZOSF-GKNBTTNJSA-N

物化性质

• 沸点：
  532.2±45.0 °C(Predicted)
• 密度：
  1.29±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  90.4
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] PHARMACEUTICAL COMPOSITIONS OF COMBINATIONS OF DIPEPTIDYL PEPTIDASE-4 INHIBITORS WITH SIMVASTATIN<br/>[FR] COMPOSITIONS PHARMACEUTIQUES DE COMBINAISONS D'INHIBITEURS DE DIPEPTIDYL PEPTIDASE-4 AVEC DE LA SIMVASTATINE
  申请人：MERCK SHARP & DOHME

  公开号：WO2012173877A1

  公开（公告）日：2012-12-20

  The present invention is directed to novel pharmaceutical compositions comprising fixed dose combinations of a dipeptidyl peptidase-4 inhibitor (DPP-4 inhibitor), or a pharmaceutically acceptable salt thereof, and simvastatin, or pharmaceutically acceptable salt thereof, methods of preparing such pharmaceutical compositions, and methods of treating Type 2 diabetes and hypercholesterolemia with such pharmaceutical compositions. In particular, the invention is directed to pharmaceutical compositions comprising fixed-dose combinations of sitagliptin phosphate and simvastatin.