羧基甲氧基琥珀酸钠盐 | 34128-01-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 羧基甲氧基琥珀酸钠盐
• 英文名称: Butanedioic acid, (carboxymethoxy)-, sodium salt
• 英文别名: trisodium 2-[(carboxymethyl)oxy]succinate；trisodium (carboxymethoxy)succinate；sodium salt of α,α'-carboxymethoxy succinic acid；trisodium salt of carboxymethyloxy succinic acid；trisodium salt of carboxymethyloxysuccinic acid；trisodium carboxymethyloxy succinate；trisodium carboxymethyloxysuccinate
• CAS: 34128-01-3；62501-41-1；77319-17-6
• 化学式: C₆H₅O₇*3Na
• 分子量: 258.071
• InChiKey: GNNQMYACPFVCRG-UHFFFAOYSA-K

计算性质

• 辛醇/水分配系数(LogP)：
  -7.98
• 重原子数：
  14.0
• 可旋转键数：
  6.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  129.62
• 氢给体数：
  0.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  氢化铕 、 羧基甲氧基琥珀酸钠盐 以 水 为溶剂， 生成
  参考文献：
  名称：

  Use of fluorescent probes for the investigation of solutions: the case of europium—carboxymethoxysuccinate complexes

  摘要：

  The investigation of Eu-cmos solutions frozen in liquid nitrogen performed under site-selective excitation and with time-resolved detection shows the existence of three different species, each characterized by one particular set of spectroscopic features (5D2 sublevels energy scheme + 5D0 --> F-7(0) emission position + 5D0 lifetime). The relative occurrence of the three species varies with the Eu:cmos ratio. In the liquid state only two 0 --> 0 lines attributed respectively to Eu(cmos) . nH2O and Eu(cmos)2 . n'H2O are observed. We have checked by comparison with frozen EuCl3 aqueous solutions that Eu3+ (aquo) is not the third species existing at LNT. We discuss its attribution to oligomeric species yet detected in Tb-cmos solutions and the influence of the ice structure on the spectroscopic characteristics of Eu3+-ligand frozen solutions.

  DOI：

  10.1016/0925-8388(92)90379-n
• 作为产物：
  描述：

  sodium glycolate 、 sodium maleate 在 lanthanum(III) chloride 作用下， 以 水 为溶剂， 反应 16.0h， 以60%的产率得到羧基甲氧基琥珀酸钠盐
  参考文献：
  名称：

  镧系元素（III）催化将乙醇酸加成到马来酸酯中。使用多核磁共振波谱研究中间体

  摘要：

  描述了镧（III）催化的乙醇酸酯向乙醇酸酯的加成反应，生成羧甲氧基琥珀酸酯（3-）（cmos）。结果表明，反应仅进行在pH 6以上，表明二羟基乙酸离子化的形成作为预平衡的限速步骤，即在加入CH的2 -O -到烯键。由于产物cmos对La III的强烈络合，因此该反应需要一种La III离子每两个cmos形成一次。非反应性强螯合剂如乙二胺四乙酸盐，次氮基三乙酸盐和2,6-吡啶二羧酸盐的抑制作用表明形成了混合配体络合物，导致加成反应。Gd III诱导的13 C弛豫速率增强和Dy III诱导的17 O位移测量已证实了这一点。

  DOI：

  10.1039/dt9880002723

文献信息

• Use of enantio-, chemo- and regioselectivity of acylase I. Resolution of polycarboxylic acid esters
  作者：Arto Liljeblad、Reijo Aksela、Liisa T. Kanerva

  DOI：10.1016/s0957-4166(01)00362-7

  日期：2001.8

  Acylase I was used to catalyze the enantioselective butanolysis of trimethyl 2-[(carboxymethyl)oxy]succinate (E=30) and N-carboxymethylaspartate (E=9) exclusively at the most sterically hindered of the three ester group's (the position alpha to the asymmetric centre). Gram-scale resolution allowed the preparation of the less reactive trimethyl (S)-2-[(carboxymethyl)oxy]succinate (96% e.e.), that of the (R)-butyldimethyl regioisomer (78% e.e.) at 55% conversion and finally the preparation of the corresponding trisodium carboxylate by saponification. Acylase I was shown to transform (+/-)-methyl N-acetylmethionine and (+/-)-valine to the corresponding (S)-amino acids through ester hydrolysis-N-acetyl transfer sequence with absolute chemo- and enantioselectivity. Butanolysis of methyl N-acetylmethionine stopped in the formation of the butyl ester (E=12), the valine derivative being totally unreactive. (C) 2001 Elsevier Science Ltd. All rights reserved.