4-(6-氨基吡啶-3-基)苯酚 | 96721-88-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 4-(6-氨基吡啶-3-基)苯酚
• 英文名称: 4-(6-Aminopyridin-3-yl)phenol
• CAS: 96721-88-9
• 化学式: C₁₁H₁₀N₂O
• 分子量: 186.213
• InChiKey: MSOVIOVREUSBPC-UHFFFAOYSA-N

物化性质

• 沸点：
  373.3±27.0 °C(Predicted)
• 密度：
  1.252±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  59.1
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(6-氨基吡啶-3-基)苯酚 、 1-[2-(2,4-difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole methanesulfonate 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以47%的产率得到1-[4-(6-Amino-3-pyridyl)phenoxy]-2-(2,4-difluorophenyl)-3-(1,2,4-triazol-1-yl)propan-2-ol
  参考文献：
  名称：

  Synthesis and SAR studies of biaryloxy-substituted triazoles as antifungal agents

  摘要：

  A series of 1-(substituted biaryloxy)-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl) propan-2-ol were synthesized and their antifungal activities were evaluated against eight human pathogenic fungi in vitro. Seventeen compounds showed activity 4-to 64-fold higher than voriconazole against Candida albicans. SAR clearly suggested that introduction of a biaryloxy side chain greatly enhanced the antifungal activity of triazole analogs against Candida species. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.04.056
• 作为产物：
  描述：

  5-(4-甲氧基苯基)-2-氨基吡啶 在 氢溴酸 作用下， 以98%的产率得到4-(6-氨基吡啶-3-基)苯酚
  参考文献：
  名称：

  Synthesis and SAR studies of biaryloxy-substituted triazoles as antifungal agents

  摘要：

  A series of 1-(substituted biaryloxy)-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl) propan-2-ol were synthesized and their antifungal activities were evaluated against eight human pathogenic fungi in vitro. Seventeen compounds showed activity 4-to 64-fold higher than voriconazole against Candida albicans. SAR clearly suggested that introduction of a biaryloxy side chain greatly enhanced the antifungal activity of triazole analogs against Candida species. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.04.056

文献信息

• Synthesis and SAR studies of biaryloxy-substituted triazoles as antifungal agents
  作者：Ping Liu、Shaolong Zhu、Peng Li、Weijie Xie、Yongsheng Jin、Qingyan Sun、Qiuye Wu、Peng Sun、Yingjun Zhang、Xiaohong Yang、Yuanying Jiang、Dazhi Zhang

  DOI：10.1016/j.bmcl.2008.04.056

  日期：2008.6

  A series of 1-(substituted biaryloxy)-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl) propan-2-ol were synthesized and their antifungal activities were evaluated against eight human pathogenic fungi in vitro. Seventeen compounds showed activity 4-to 64-fold higher than voriconazole against Candida albicans. SAR clearly suggested that introduction of a biaryloxy side chain greatly enhanced the antifungal activity of triazole analogs against Candida species. (C) 2008 Elsevier Ltd. All rights reserved.