3,3'-p-Toluiden-bis-(6-brom-4-hydroxy-cumarin) und Tautomeres | 4224-76-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 3,3'-p-Toluiden-bis-(6-brom-4-hydroxy-cumarin) und Tautomeres
• 英文别名: 6,6'-dibromo-4,4'-dihydroxy-3,3'-p-tolylmethanediyl-bis-chromen-2-one；6-Bromo-3-[(6-bromo-4-hydroxy-2-oxochromen-3-yl)-(4-methylphenyl)methyl]-4-hydroxychromen-2-one
• CAS: 4224-76-4
• 化学式: C₂₆H₁₆Br₂O₆
• 分子量: 584.217
• InChiKey: FKCNCTLOZKQEFG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  34
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  93.1
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  对甲基苯甲醛 、 6-溴-4-羟基香豆素 在 哌啶 、 硫酸 作用下， 以 乙醇 为溶剂， 生成 3,3'-p-Toluiden-bis-(6-brom-4-hydroxy-cumarin) und Tautomeres
  参考文献：
  名称：

  Synthesis, Characterization, and Biological Studies of Metal Complexes of Dicoumarol Derivatives of Gatifloxacin

  摘要：

  Copper(II) complexes were prepared using gatifloxacin and dicoumarin derivatives to investigate their biological activities and to conduct X-ray studies. The complexes were synthesized through classical thermal methods. Biologically potent ligands were synthesized by the reaction of dicoumarin derivative with different aldehydes in ethanol. Cu(II) complexes were formed by mixing ethanolic solution of ligands and gatifloxacin with metal solutions in a 1:1 mole ratio. The structures of the dicoumarin derivatives and their Cu(II) complexes were analyzed by infrared, 1H NMR, 13C NMR, and mass spectrometry. The thermal behavior of the new mixed ligand Cu(II) complexes was investigated by thermogravimetric, fast atom bombardment (FAB) mass, and X-ray analysis. The iron-reducing antioxidant potential (FRAP) (antioxidant activity) of all compounds was evaluated. All the synthesized compounds were screened for antibacterial activity against Escherichia coli; Pseudomonas aeruginosa; Streptococcus pyogenes; minimum inhibitory concentration values for Candida albicans; and Aspergillus niger were determined using the Luria Broth dilution method. The ligands and their complexes were evaluated for antioxidant and antibacterial activity in vitro. The complexes exhibited better results than their respective counterparts.. KEYWORDS :Antimicrobial, Antioxidant, Fast atom bombardment mass, Thermal analysis, Thermo gravimetric analysis, X-ray.

  DOI：

  10.59467/ijhc.2024.34.15

文献信息

• Bis-(Coumarin) Compounds With Anti-Inflammatory Activity
  申请人：Mercep Mladen

  公开号：US20080153872A1

  公开（公告）日：2008-06-26

  Certain bis-(coumarin) compounds as well as the products of their intramolecular cyclization including pharmaceutically acceptable salts, hydrates, solvates, clathrates, prodrugs, tautomers and stereoisomers thereof are disclosed. Certain processes and intermediates for the preparation of certain bis-(coumarin) compounds, as well as for the use of these compounds as therapeutically active agents in the prophylaxis and treatment of asthma and other inflammatory diseases and conditions in mammals, especially humans are also disclosed.