Pglu-Gly-Arg p-nitroanilide hydrochloride | 72194-52-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Pglu-Gly-Arg p-nitroanilide hydrochloride
• 英文别名: (2S)-N-[2-[[(2S)-5-(diaminomethylideneamino)-1-(4-nitroanilino)-1-oxopentan-2-yl]amino]-2-oxoethyl]-5-oxopyrrolidine-2-carboxamide;hydrochloride
• CAS: 72194-52-6；115389-02-1
• 化学式: C19H27ClN8O6
• 分子量: 498.9
• InChiKey: PZDJIXYQYPADDW-IODNYQNNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.62
• 重原子数：
  34
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.421
• 拓扑面积：
  227
• 氢给体数：
  7
• 氢受体数：
  7

文献信息

• A thrombolytic agent
  申请人：Amano Seiyaku Kabushiki Kaisha

  公开号：EP0105092A2

  公开（公告）日：1984-04-11

  The invention discloses that the tissues of earthworms contain fibrinolytically or thrombolytically active ingredients which can be extracted and purified by a suitable sequence of extraction and purification procedures into the individual active ingredients including six novel proteases named F-OHM-45, F-I-1-HM-54, F-1-2-HM-15, F-II-HM-64, F-III-1-HM-27 and F-III-2-HM-89. The chromatographic fractionation of the earthworm extract with an aqueous extractant gives five active fractions, the first four of which contain each one of the first mentioned four proteases and the last of which contains the last mentioned two proteases. The disclosure includes description of the suitable purification methods for the proteases as well as the physico-chemical identification data thereof. Various thrombolytic medicament forms prepared with the novel proteases as the effective ingredient are described together with the results of the clinical tests carried out by the oral administration of the novel proteases.

  本发明公开了蚯蚓组织中含有纤维蛋白溶解或血栓溶解活性成分，可通过适当的提取和纯化程序提取和纯化为单个活性成分，包括六种新型蛋白酶，分别命名为F-OHM-45、F-I-1-HM-54、F-1-2-HM-15、F-II-HM-64、F-III-1-HM-27和F-III-2-HM-89。用水性萃取剂对蚯蚓提取物进行色谱分馏，可得到五个活性馏分，其中前四个馏分分别含有前述四种蛋白酶中的每一种，最后一个馏分含有后述两种蛋白酶。公开内容包括蛋白酶的合适纯化方法及其物理化学鉴定数据。此外，还介绍了以新型蛋白酶为有效成分制备的各种溶栓药物，以及通过口服新型蛋白酶进行临床试验的结果。
• PLATELET SPECIFIC IMMUNOCONJUGATES
  申请人：CENTOCOR, INC.

  公开号：EP0465556B1

  公开（公告）日：1995-06-28
• TRYPSIN INHIBITORS
  申请人：CORVAS INTERNATIONAL, INC.

  公开号：EP0627925A1

  公开（公告）日：1994-12-14
• EP0627925A4
  申请人：——

  公开号：EP0627925A4

  公开（公告）日：1997-07-30
• US4568545A
  申请人：——

  公开号：US4568545A

  公开（公告）日：1986-02-04