1,7-heptanediol mononitrate | 402725-65-9

• 分子结构分类: 有机化合物 - 有机氧化合物 - 有机含氧阴离子化合物
• 英文名称: 1,7-heptanediol mononitrate
• 英文别名: 7-Hydroxyheptyl nitrate
• CAS: 402725-65-9
• 化学式: C₇H₁₅NO₄
• 分子量: 177.2
• InChiKey: MMKZFZCDRHXFOI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  12
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  75.3
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] PROCESS FOR THE MANUFACTURE OF OMEGA NITROOXY-1-ALKANOLS<br/>[FR] PROCÉDÉ DE FABRICATION D'OMÉGA NITROOXY-1-ALCANOLS
  申请人：DSM IP ASSETS BV

  公开号：WO2020053194A1

  公开（公告）日：2020-03-19

  The invention relates to a process for the preparation of ω-nitroxyC3-1 0 alkane-1-ols comprising the nitration of an α,ω-C 3-10 alkanediol with a nitration agent, optionally in the presence of a nitrite trapping agent, characterized in that the nitration agent is a mixture consisting of 50 to 75 wt.-% of nitric acid in water wherein the nitric acid is used in an amount selected in the range from 0.5 to 5 mol equivalents based on the α,ω--C3-10alkanediols, and wherein the nitration is carried out at a temperature selected in the range from 65 - 100°C.

  该发明涉及一种制备ω-硝基C3-10烷基-1-醇的方法，包括将α，ω-C3-10烷二醇与硝化剂进行硝化，可选地在存在硝酸盐捕获剂的情况下，其特征在于硝化剂是由50至75重量％硝酸在水中组成的混合物，其中硝酸的用量选择在0.5至5摩尔当量范围内，基于α，ω-C3-10烷二醇，并且硝化在65-100°C范围内的温度下进行。
• [EN] PROCESS FOR THE ACYLATION OF AN ALPHA, OMEGA-ALKANEDIOL<br/>[FR] PROCÉDÉ D'ACYLATION D'UN ALPHA, OMÉGA-ALCANEDIOL
  申请人：DSM IP ASSETS BV

  公开号：WO2021214146A1

  公开（公告）日：2021-10-28

  The invention relates to a safe and efficient process for the for the acylation of an α,ω-alkanediol, which can be used in the manufacture of ω-nitrooxy-C3-10alkane-1-ols. The process is safer to operators and allows to obtain advantageous yields on industrial scale.

  该发明涉及一种安全高效的α,ω-烷二醇酰化过程，可用于制造ω-硝基氧基-C3-10烷基醇。该过程对操作人员更安全，并且能够在工业规模上获得有利的产量。
• NITRIC OXIDE DONATING DIURETIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE
  申请人：GARVEY David S.

  公开号：US20080255101A1

  公开（公告）日：2008-10-16

  The invention describes novel compositions and kits comprising at least one nitric oxide enhancing diuretic compound, or pharmaceutically acceptable salts thereof, and, optionally, at least one nitric oxide enhancing compound and/or at least one therapeutic agent. The invention also provides methods for (a) treating conditions resulting from excessive water and/or electrolyte retention; (b) treating cardiovascular diseases; (c) treating renovascular diseases; (d) treating diabetes; (e) treating diseases resulting from oxidative stress; (f) treating endothelial dysfunctions; (g) treating diseases caused by endothelial dysfunctions; (h) treating cirrhosis; (j) treating pre-eclampsia; (k) treating osteoporosis; (l) treating nephropathy; (m) treating peripheral vascular diseases; (n) treating portal hypertension; (o) treating central nervous system disorders; (p) treating metabolic syndrome; (q) treating sexual dysfunctions; and (r) hyperlipidemia. The nitric oxide enhancing diuretic compounds comprise at least one nitric oxide enhancing group linked to the diuretic compound through one or more sites such as carbon, oxygen and/or nitrogen via a bond or moiety that cannot be hydrolyzed.

  这项发明描述了新颖的组合物和试剂盒，包括至少一种增强一氧化氮利尿化合物或其药学上可接受的盐，并且可选地，还包括至少一种增强一氧化氮化合物和/或至少一种治疗剂。该发明还提供了以下方法：(a)治疗由过度水和/或电解质潴留引起的疾病；(b)治疗心血管疾病；(c)治疗肾血管疾病；(d)治疗糖尿病；(e)治疗由氧化应激引起的疾病；(f)治疗内皮功能障碍；(g)治疗由内皮功能障碍引起的疾病；(h)治疗肝硬化；(j)治疗先兆子痫；(k)治疗骨质疏松症；(l)治疗肾病；(m)治疗外周血管疾病；(n)治疗门静脉高压；(o)治疗中枢神经系统疾病；(p)治疗代谢综合征；(q)治疗性功能障碍；以及(r)治疗高脂血症。增强一氧化氮利尿化合物包括至少一个增强一氧化氮基团，通过碳、氧和/或氮等一个或多个位点连接到利尿化合物上，通过无法水解的键或基团连接。
• PROCESS FOR THE MANUFACTURE OF OMEGA NITROOXY-1-ALKANOLS
  申请人：DSM IP Assets B.V.

  公开号：EP3849340A1

  公开（公告）日：2021-07-21
• AQUEOUS COMPOSITIONS COMPRISING OMEGA NITROOXY-1-ALKANOLS
  申请人：DSM IP ASSETS B.V.

  公开号：US20210392922A1

  公开（公告）日：2021-12-23

  The invention relates to safe aqueous compositions of ω-nitrooxy-C3-10alkane-1-ols.