3-Bromo-6-Phenyl-N-(Pyrimidin-5-Ylmethyl)imidazo[1,2-A]pyridin-8-Amine | 676370-63-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 3-Bromo-6-Phenyl-N-(Pyrimidin-5-Ylmethyl)imidazo[1,2-A]pyridin-8-Amine
• CAS: 676370-63-1
• 化学式: C₁₈H₁₄BrN₅
• 分子量: 380.247
• InChiKey: LZLKFNBMXXLTLX-UHFFFAOYSA-N

物化性质

• 密度：
  1.51±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  55.1
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• IMIDAZOPYRIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS
  申请人：Schering Corporation

  公开号：EP1539756B1

  公开（公告）日：2007-11-14
• IDENTIFICATION AND TARGETED MODULATION OF GENE SIGNALING NETWORKS
  申请人：CAMP4 THERAPEUTICS CORPORATION

  公开号：US20210254056A1

  公开（公告）日：2021-08-19

  The present invention provides methods and compositions for the evaluation, alteration and/or optimization of gene signaling. Methods and systems are also provided which exploit the information generated in the identification of new targets and non-canonical signaling pathways.
• US7452902B2
  申请人：——

  公开号：US7452902B2

  公开（公告）日：2008-11-18
• [EN] METHODS AND SYSTEMS OF STRATIFYING INFLAMMATORY DISEASE PATIENTS<br/>[FR] PROCÉDÉS ET SYSTÈMES POUR STRATIFICATION DE PATIENTS ATTEINTS DE MALADIE INFLAMMATOIRE
  申请人：[en]CEDARS-SINAI MEDICAL CENTER

  公开号：WO2022119842A1

  公开（公告）日：2022-06-09

  Described herein are methods and systems for identifying subpopulations of inflammatory bowel disease (IBD) patients utilizing genetic markers that are associated with severe Crohn's disease. Further provided are therapies useful for treating these subpopulations of IBD patients based, at least in part, on the genetic markers provided herein.