6H-pyrrolo[3,2-d]thiazole-5-carboxylic acid amide | 881888-44-4

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: 6H-pyrrolo[3,2-d]thiazole-5-carboxylic acid amide
• 英文别名: 4H-pyrrolo[3,2-d][1,3]thiazole-5-carboxamide
• CAS: 881888-44-4
• 化学式: C₆H₅N₃OS
• 分子量: 167.191
• InChiKey: ATWKMDVPLBSOQU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  100
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• SUBSTITUTED THIENOPYRROLE CARBOXYLIC ACID AMIDES, PYRROLOTHIAZOLE CARBOXYLIC ACID AMIDES, AND RELATED ANALOGS AS INHIBITORS OF CASEIN KINASE I
  申请人：Fink Marc David

  公开号：US20070299112A1

  公开（公告）日：2007-12-27

  The present invention discloses and claims compounds of formula (I) and formula (II), as inhibitors of human casein kinase Iε and methods for using said compounds for treating central nervous system diseases and disorders including mood disorders and sleep disorders. Pharmaceutical compositions comprising compounds of formula (I) or formula (II) and a method for the preparation of compounds of formula (I) or formula (II) are also disclosed and claimed.

  本发明揭示和声明公式(I)和公式(II)的化合物，作为人类酪蛋白激酶Iε的抑制剂，并提供使用这些化合物治疗中枢神经系统疾病和紊乱，包括情绪障碍和睡眠障碍的方法。还揭示和声明了包含公式(I)或公式(II)化合物的药物组合物，以及制备公式(I)或公式(II)化合物的方法。
• SUBSTITUTED THIENOPYRROLE CARBOXYLIC ACID AMIDES, PYRROLOTHIAZOLE CARBOXYLIC ACID AMIDES, AND RELATED ANALOGS AS INHIBITORS OF CASEIN KINASE I EPSILON
  申请人：Aventis Pharmaceuticals Inc.

  公开号：EP1784409B1

  公开（公告）日：2010-06-16
• US7393867B2
  申请人：——

  公开号：US7393867B2

  公开（公告）日：2008-07-01
• US7652046B2
  申请人：——

  公开号：US7652046B2

  公开（公告）日：2010-01-26
• [EN] THIAZOLE CARBOXAMIDE COMPOUNDS AND USE THEREOF FOR THE TREATMENT OF MYCOBACTERIAL INFECTIONS<br/>[FR] COMPOSÉS DE THIAZOLE CARBOXAMIDE ET LEUR UTILISATION POUR LE TRAITEMENT D'INFECTIONS MYCOBACTÉRIENNES
  申请人：THE GLOBAL ALLIANCE FOR TB DRUG DEV INC

  公开号：WO2021062318A1

  公开（公告）日：2021-04-01

  Provided herein are compounds of Formula (I) and Formula (II) as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of tuberculosis.