2-cyano-3t-methoxy-acrylic acid ethyl ester | 42466-70-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 乙烯酯类
• 英文名称: 2-cyano-3t-methoxy-acrylic acid ethyl ester
• 英文别名: 2-cyano-3-methoxy-acrylic acid ethyl ester；(E)-Methoxymethylen-malonsaeure-aethylester-nitril；2-Cyan-3t-methoxy-acrylsaeure-aethylester；Methoxymethylen-cyanessigsaeure-aethylester；2-Cyan-3-methoxy-acrylsaeure-aethylester；E-2-Cyano-3-methoxy-acrylsaeureethylester；2-Propenoic acid, 2-cyano-3-methoxy-, ethyl ester；ethyl (E)-2-cyano-3-methoxyprop-2-enoate
• CAS: 42466-70-6
• 化学式: C₇H₉NO₃
• 分子量: 155.153
• InChiKey: KAFVHDPIBCRLNV-AATRIKPKSA-N

物化性质

• 沸点：
  272.9±7.0 °C(Predicted)
• 密度：
  1.102±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  59.3
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-cyano-3t-methoxy-acrylic acid ethyl ester 、 氯仿 生成 alkaline earth salt of/the/ methylsulfuric acid
  参考文献：
  名称：

  2-吡啶基和4-羟基苯基-1,4-二氢吡啶衍生物的实验和理论结构研究

  摘要：

  按照众所周知的对称1,4-DHP的Hantzsch程序合成了一系列取代的1,4-二氢吡啶（1,4-DHP）。这些化合物的结构已通过X射线晶体学分析和半经验（AMI）计算进行了深入研究。在理论和实验结果之间找到了很好的一致性。在所有情况下，最稳定的构象均满足显示拮抗剂钙效应所需的所有要求。

  DOI：

  10.1002/jhet.5570370627
• 作为产物：
  描述：

  氰乙酸乙酯 、 原甲酸三甲酯 在 乙酸酐 作用下， 生成 2-cyano-3t-methoxy-acrylic acid ethyl ester
  参考文献：
  名称：

  一些 1-烷氧基-2,2-二（羰基、羧基、氰基）取代的乙烯的 NMR 光谱数据

  摘要：

  报道了 14 烷氧基亚甲基丙二酸和乙酰乙酸衍生物以及两种烷氧基亚甲基乙酰丙酮的 1H-13C NMR 位移以及 1H 和 13C 偶联常数。已记录了其中六个的 17O 核磁共振谱。长程耦合 3J(HCCCR) 已用于确定双键的立体化学。版权所有 © 2004 John Wiley & Sons, Ltd.

  DOI：

  10.1002/mrc.1522

文献信息

• [EN] NOVEL COMPOUNDS AS AGONIST FOR PPAR GAMMA AND PPAR ALPHA, METHOD FOR PREPARATION OF THE SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME<br/>[FR] NOUVEAUX COMPOSES AGONISTES DE PPAR DOLLAR G(G) ET PPAR DOLLAR G(A), LEUR METHODE DE PREPARATION ET COMPOSITION PHARMACEUTIQUE LES CONTENANT
  申请人：LG LIFE SCIENCES LTD

  公开号：WO2005040127A1

  公开（公告）日：2005-05-06

  The present invention relates to novel compounds accelerating the activity of Peroxisome proliferator-activated receptor gamma (PPARϜ) and alpha (PPARα), processes of preparing the same, and pharmaceutical compositions containing the same as an active agent.

  本发明涉及一种新型化合物，可加速过氧化物酶体增殖物激活受体γ（PPARϜ）和α（PPARα）的活性，以及制备这种化合物的方法，以及含有该化合物作为活性成分的药物组合物。
• 2-(2 Or 4-substituted aryloxy)-phenol derivatives as antibacterial agents
  申请人：Huang Liren

  公开号：US20060211697A1

  公开（公告）日：2006-09-21

  Antimicrobial compounds, compositions and methods of treatment administering same, of 2-aryloxyphenol derivatives having a heterocyclic or polar functional substitution attached through a N—C or C—C bond at the position para or ortho relative to oxygen bridge on non-phenolic phenyl ring, as well as methods for their preparation and formation, wherein the compounds are generally of Formula 1 and Formula 2:

  抗微生物化合物、组合物和治疗方法，其治疗方法是给予2-芳氧基苯酚衍生物，其在非酚苯环上的氧桥相对位置上通过N-C或C-C键连接有杂环或极性功能基团，以及它们的制备和形成方法，其中化合物通常为公式1和公式2：
• Herbicide and plant growth regulator comprising alpha-beta-unsaturated compound
  申请人：TEIJIN LIMITED

  公开号：EP0104432A2

  公开（公告）日：1984-04-04

  A herbicide comprising as an active ingredient an α,β-unsaturated compound of the following formula (I) wherein each of R' and R2 represents CN, NO2, a halogen, a C1-25 alkoxy or alkylthio, a group of the formula in which Z' represents C1-25 alkyl or a phenyl, a group of the formula in which X's represent an oxygen or sulfur atom and Z2 represents hydrogen, one equivalent of a cation, C1-25 alkyl, a phenyl or a phenyl (C1-25 alkyl), a group of the formula

  一种除草剂，其活性成分为下式（I）的α，β-不饱和化合物 其中 R'和 R2 各自代表 CN、NO2、卤素、C1-25 烷氧基或烷基硫代、一个式中的基团 其中 Z'代表 C1-25 烷基或苯基，一个式基团 式中 X 代表氧原子或硫原子，Z2 代表氢、一个当量的阳离子、C1-25 烷基、苯基或苯基（C1-25 烷基）、一个式基团
• GLUE LAMINATION CORE FOR STATORS AND METHOD FOR MANUFACTURING SAME, AND ROTATING ELECTRICAL MACHINE
  申请人：NIPPON STEEL CORPORATION

  公开号：EP3902112A1

  公开（公告）日：2021-10-27

  An adhesively-laminated core for a stator capable of suppressing an iron loss of an electric motor and also having excellent productivity is provided. The adhesively-laminated core for a stator includes a plurality of electrical steel sheets which are stacked on one another and of which both surfaces are coated with insulation coatings, and adhesion parts which are disposed between the electrical steel sheets adjacent to each other in a stacking direction and cause the electrical steel sheets to be adhered to each other. All sets of the electrical steel sheets adjacent to each other in the stacking direction are adhered via the adhesion parts. An adhesive forming the adhesion parts is a two-agent type acrylic-based adhesive (SGA) which includes an acrylic-based compound, an oxidizer, and a reducer and in which a portion of the acrylic-based compound and the oxidizer are assigned to a first agent and the remaining portion of the acrylic-based compound and the reducer are assigned to a second agent. The adhesion parts are partially provided between the electrical steel sheets adjacent to each other in the stacking direction.

  本发明提供了一种用于定子的粘合层叠铁芯，它能够抑制电机的铁损，同时还具有出色的生产率。用于定子的粘合层叠铁芯包括多个相互堆叠且两面均涂有绝缘涂层的电工钢片，以及设置在堆叠方向上相互邻近的电工钢片之间并使电工钢片相互粘合的粘合部件。在堆叠方向上相邻的各组电工钢片通过粘附部件粘附在一起。形成粘附部件的粘合剂是一种双剂型丙烯酸基粘合剂（SGA），它包括丙烯酸基化合物、氧化剂和还原剂，其中丙烯酸基化合物和氧化剂的一部分分配给第一剂，丙烯酸基化合物和还原剂的剩余部分分配给第二剂。在堆叠方向上相邻的电工钢板之间部分地设置了粘合部件。
• Cyanoacrylate medical adhesive and preparation method and use thereof
  申请人：Shen Wei

  公开号：US10471174B2

  公开（公告）日：2019-11-12

  The invention relates to a novel cyanoacrylate medical adhesive and preparation method and application thereof, the main components of the medical adhesive is composed of alkyl cyanoacrylate and/or alkoxy cyanoacrylate and lactyl cyanoacrylate, and by adding a novel stabilizer system, the stability of the novel cyanoacrylate medical adhesive product in the invention increases substantially, the product can be stored and transported at room temperature, degradation performance of the product was greatly improved, the main technical indicators of product such as curing time and mechanical properties can meet the clinical needs, and the user experience of the product such as adhesive film flexibility is greatly improved, so the cyanoacrylate medical adhesive is an widely used surgical hemostatic materials.

  本发明涉及一种新型氰基丙烯酸酯医用胶粘剂及其制备方法和应用，该医用胶粘剂的主要成分由氰基丙烯酸烷基酯和/或氰基丙烯酸烷氧基酯、氰基丙烯酸乳酯组成，通过添加新型稳定剂体系，使本发明新型氰基丙烯酸酯医用胶粘剂产品的稳定性大幅提高、该产品可在常温下储存和运输，产品的降解性能得到极大改善，产品的主要技术指标如固化时间和机械性能等均能满足临床需要，产品的用户体验如胶膜的柔韧性等也得到极大改善，因此该氰基丙烯酸酯医用胶粘剂是一种应用广泛的外科止血材料。

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