[3-(2-Methyl-thiazol-4-yl)-phenyl]-thiourea | 1210461-20-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [3-(2-Methyl-thiazol-4-yl)-phenyl]-thiourea
• 英文别名: [3-(2-methyl-1,3-thiazol-4-yl)phenyl]thiourea
• CAS: 1210461-20-3
• 化学式: C₁₁H₁₁N₃S₂
• 分子量: 249.36
• InChiKey: SODFLFCFOOEBNA-UHFFFAOYSA-N

物化性质

• 沸点：
  432.7±47.0 °C(Predicted)
• 密度：
  1.371±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  111
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  [3-(2-Methyl-thiazol-4-yl)-phenyl]-thiourea 、 N-[4-(2-溴乙酰基)苯基)乙酰胺 以 乙醇 为溶剂， 反应 4.0h， 以79%的产率得到N-[4-[2-[3-(2-methyl-1,3-thiazol-4-yl)anilino]-1,3-thiazol-4-yl]phenyl]acetamide
  参考文献：
  名称：

  Synthesis and Anticancer Activities of Some Thiazole Derivatives

  摘要：

  In this study, 2-substituted 4-[3/4-(4-arylthiazole-2-yl) aminophenyl] thiazole derivatives and 2-[4-[2-substituted 4-methylthiazole-5-yl]thiazole-2-yl] amino-5-arylidenethiazoline-4-one derivatives have been synthesized. The cytotoxic and/or growth inhibitory effects of the 16 selected compounds were evaluated in vitro against approximately 66 human tumor cell lines derived from nine neoplastic diseases. Some of the compounds were found to act as anticancer agents.

  DOI：

  10.1080/10426500802446181
• 作为产物：
  描述：

  硫氰酸铵 、 3-(2-甲基-1,3-噻唑-4-基)苯胺 在 盐酸 、 水 作用下， 生成 [3-(2-Methyl-thiazol-4-yl)-phenyl]-thiourea
  参考文献：
  名称：

  Synthesis and Anticancer Activities of Some Thiazole Derivatives

  摘要：

  In this study, 2-substituted 4-[3/4-(4-arylthiazole-2-yl) aminophenyl] thiazole derivatives and 2-[4-[2-substituted 4-methylthiazole-5-yl]thiazole-2-yl] amino-5-arylidenethiazoline-4-one derivatives have been synthesized. The cytotoxic and/or growth inhibitory effects of the 16 selected compounds were evaluated in vitro against approximately 66 human tumor cell lines derived from nine neoplastic diseases. Some of the compounds were found to act as anticancer agents.

  DOI：

  10.1080/10426500802446181

文献信息

• Synthesis and Anticancer Activities of Some Thiazole Derivatives
  作者：Ismail Kayagil、Seref Demirayak

  DOI：10.1080/10426500802446181

  日期：2009.9.18

  In this study, 2-substituted 4-[3/4-(4-arylthiazole-2-yl) aminophenyl] thiazole derivatives and 2-[4-[2-substituted 4-methylthiazole-5-yl]thiazole-2-yl] amino-5-arylidenethiazoline-4-one derivatives have been synthesized. The cytotoxic and/or growth inhibitory effects of the 16 selected compounds were evaluated in vitro against approximately 66 human tumor cell lines derived from nine neoplastic diseases. Some of the compounds were found to act as anticancer agents.