[Pt(2,2'-dipyridylamine)(1,1-cyclobutanedicarboxylate)] | 671185-14-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: [Pt(2,2'-dipyridylamine)(1,1-cyclobutanedicarboxylate)]
• 英文别名: [Pt(dpa)CBDCA]；cyclobutane-1,1-dicarboxylate;platinum(2+);N-pyridin-2-ylpyridin-2-amine
• CAS: 671185-14-1
• 化学式: C₁₆H₁₅N₃O₄Pt
• 分子量: 508.393
• InChiKey: HTGTVBNEQCIQLL-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  2,2'-二吡啶胺 、 (cyclobutane-1,1-dicarboxylate)bis(dimethylsulfoxide)platinum(II) 以 甲醇 为溶剂， 以83%的产率得到[Pt(2,2'-dipyridylamine)(1,1-cyclobutanedicarboxylate)]
  参考文献：
  名称：

  Crystal structure, DNA-binding ability and cytotoxic activity of platinum(II) 2,2′-dipyridylamine complexes

  摘要：

  Two platinum(II) complexes, [Pt(dpa)Cl-2] (1) and [Pt(dpa)CBDCA] (2), where DPA = 2,2'-dipyridylamine and CBDCA = 1,1-cyclobutanedicarboxylate, were synthesized and characterized by elemental analysis, IR spectroscopy, ES-MS and X-ray diffraction. Intermolecular hydrogen bonds were observed in both complexes (N-H...Cl for complex I and N-(HO)-O-... for complex 2), which may play a role in formation of hydrogen bonding in metal-DNA adducts. Complex 2 adopts a boat conformation so that the cyclobutane ring and bipyridyl groups are on the same side of the platinum square. The interactions of complexes I and 2 with DNA were studied by UV and Fluorescence Spectroscopy, which indicated that both complexes could interact with DNA through groove binding or intercalation. The in vitro cytotoxic activity against melanoma B16-BL6 cells and human Jurkat T-cells was also reported. (C) 2003 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/s0020-1693(03)00389-x