4-hydroxy-5-(4-hydroxyphenyl)-3-phenyl-6,7-dihydro-thieno[2,3-b]pyridin-6-one | 1190766-08-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 4-hydroxy-5-(4-hydroxyphenyl)-3-phenyl-6,7-dihydro-thieno[2,3-b]pyridin-6-one
• 英文别名: 4-hydroxy-5-(4-hydroxyphenyl)-3-phenyl-7H-thieno[2,3-b]pyridin-6-one
• CAS: 1190766-08-5
• 化学式: C₁₉H₁₃NO₃S
• 分子量: 335.383
• InChiKey: JJJGDUXRYVICBF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  97.8
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• THIENOPYRIDONE DERIVATIVES AS AMP-ACTIVATED PROTEIN KINASE (AMPK) ACTIVATORS
  申请人：Cravo Daniel

  公开号：US20110034505A1

  公开（公告）日：2011-02-10

  The present invention relates to compounds of formula (I) wherein R1, R2 and R3 are as defined in claim 1 , including pharmaceutical compositions thereof and for their use in the treatment and/or prevention of diseases and disorders modulated by AMP agonists. The invention is also directed to intermediates and to a method of preparation of compounds of formula (I).

  本发明涉及式（I）化合物，其中R1、R2和R3如权利要求1所定义，包括其药物组合物以及用于治疗和/或预防由AMP激动剂调节的疾病和紊乱的用途。该发明还涉及中间体和式（I）化合物的制备方法。
• US8563729B2
  申请人：——

  公开号：US8563729B2

  公开（公告）日：2013-10-22