3-p-toluidino-pentenedioic acid diethyl ester | 177971-66-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-p-toluidino-pentenedioic acid diethyl ester
• 英文别名: 3-p-Toluidino-pentendisaeure-diaethylester；β-p-Tolylimino-glutarsaeure-diaethylester；β-p-Toluidino-glutaconsaeure-diaethylester；diethyl (E)-3-(4-methylanilino)pent-2-enedioate
• CAS: 177971-66-3
• 化学式: C₁₆H₂₁NO₄
• 分子量: 291.347
• InChiKey: OTVMILYZEBNJNO-GXDHUFHOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  21
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  64.6
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3-p-toluidino-pentenedioic acid diethyl ester 在 二乙二醇二乙醚 、 polychloro-biphenyl 、 三氯氧磷 作用下， 生成 (4-chloro-6-methyl-[2]quinolyl)-acetic acid ethyl ester
  参考文献：
  名称：

  SUBSTITUTED QUINOLINEACETIC ACIDS¹

  摘要：

  DOI：

  10.1021/jo01146a011
• 作为产物：
  描述：

  (Z)-3-p-Tolylamino-pent-2-enedioic acid diethyl ester 在 对甲苯磺酸 作用下， 以 氘代二甲亚砜 为溶剂， 生成 3-p-toluidino-pentenedioic acid diethyl ester
  参考文献：
  名称：

  Isomerization of N-aryl substituted diethyl 3-aminoglutaconates. Part I

  摘要：

  Diethyl acetonedicarboxylate 1 under acid catalysis reacts with aromatic amines and 2-aminonitriles 2 forming N-aryl substituted diethyl 3-aminoglutaconates 3. The structures of the products 3 were studied both in the solid and the liquid state. The presence of the double bond permits two isomeric forms. These E and Z isomers can interchange with one another under catalysis by either an acid or a base in a suitable solvent. The isomeric equilibriums were studied by H-1 NMR spectroscopy with respect to dependence on the polarity of the solvent, the temperature and the substitution present on the aromatic skeleton.

  DOI：

  10.1016/0022-2860(95)09135-1

文献信息

• Mexico's stalled peace process: prospects and challenges
  作者：Nicholas P. Higgins

  DOI：10.1111/1468-2346.00224

  日期：2001.10

  High hopes were raised when Vicente Fox Quesada of the National Action Party (PAN) was elected President of Mexico in July 2000. After three years of inaction, the possibility that the nation's stalled peace process might once again recommence suddenly seemed plausible. With the announcement in December 2000 by the rebel Zapatista Army of National Liberation (EZLN) of three preconditions prior to any dialogue taking place, a clear trajectory was set. Four months later, however, all contact with the rebels had been broken and once again Mexico's peace process was in jeopardy. This article recounts the brief history of talks to date and explains how the current impasse has been reached. Identifying both prospects and challenges for any future peace deal, the author calls for greater international vigilance and understanding of a conflict with significant political and ethical implications.

  2000 年 7 月，国家行动党（PAN）的比森特-福克斯-克萨达（Vicente Fox Quesada）当选墨西哥总统，人们对此寄予厚望。在三年无所作为之后，墨西哥停滞不前的和平进程突然有可能重新启动。2000 年 12 月，叛军萨帕塔民族解放军（EZLN）宣布了进行任何对话之前的三个先决条件，这为和平进程设定了明确的轨道。然而，四个月后，与叛军的所有联系都中断了，墨西哥的和平进程再一次岌岌可危。本文回顾了迄今为止会谈的简要历史，并解释了目前的僵局是如何形成的。作者指出了未来和平协议的前景和挑战，呼吁国际社会提高警惕，理解这场具有重大政治和道德影响的冲突。
• Schroeter, Chemische Berichte, 1905, vol. 38, p. 3189
  作者：Schroeter

  DOI：——

  日期：——
• Munavalli et al., Journal of the Karnatak University, 1956, vol. 1, p. 23,26
  作者：Munavalli et al.

  DOI：——

  日期：——