UNC3575A | 1603945-83-0

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: UNC3575A
• 英文别名: UNC3575
• CAS: 1603945-83-0
• 化学式: C₃₀H₄₁N₇O
• 分子量: 515.702
• InChiKey: CKXRORPPELJEDD-SOAUALDESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.42
• 重原子数：
  38.0
• 可旋转键数：
  8.0
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  82.34
• 氢给体数：
  2.0
• 氢受体数：
  8.0

文献信息

• THERAPEUTIC USES OF SELECTED PYRAZOLOPYRIMIDINE COMPOUNDS WITH ANTI-MER TYROSINE KINASE ACTIVITY
  申请人：The University of North Carolina at Chapel Hill

  公开号：US20150290212A1

  公开（公告）日：2015-10-15

  Pyrazolopyrimidine compounds, methods of use, and processes for making compounds with anti-Mer tyrosine kinase activity comprising Formula I, II, III, IV, or a pharmaceutically acceptable composition, salt, isotopic analog, or prodrug thereof, are provided. The pyrazolopyrimidine compounds described herein have Mer tyrosine kinase (MerTK) inhibitory activity and are useful as anti-infective agents, immunostimulatory and immunomodulatory agents, anti-cancer agents (including against MerTK −/− tumors and ITD and TKD mutant forms of Acute Myeloid Leukemia (AML)), and as adjunctive agents in combination with chemotherapeutic, radiation or other standard of care for neoplasms.

  本文提供了具有抗Mer酪氨酸激酶活性的化合物公式I、II、III、IV或其药学上可接受的组合物、盐、同位素类似物或前药的使用方法和制备过程。这些在此处描述的吡唑并嘧啶化合物具有Mer酪氨酸激酶(MerTK)抑制活性，并且可用作抗感染剂、免疫刺激和免疫调节剂、抗癌剂(包括对MerTK -/-肿瘤和急性髓细胞白血病的ITD和TKD突变体)以及作为伴随化疗、放疗或其他肿瘤标准治疗的辅助剂。
• PYRAZOLOPYRIMIDINE COMPOUNDS FOR THE TREATMENT OF CANCER
  申请人：THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL

  公开号：US20150284392A1

  公开（公告）日：2015-10-08

  Compounds of Formula I are described, along with pharmaceutically acceptable salts thereof, compositions containing the same, and methods of use thereof.

  描述了化学式I的化合物及其药学上可接受的盐，包含这些化合物的组合物，以及使用这些化合物的方法。
• US9555030B2
  申请人：——

  公开号：US9555030B2

  公开（公告）日：2017-01-31
• US9562047B2
  申请人：——

  公开号：US9562047B2

  公开（公告）日：2017-02-07
• [EN] THERAPUETIC USES OF SELECTED PYRAZOLOPYRIMIDINE COMPOUNDS WITH ANTI-MER TYROSINE KINASE ACTIVITY<br/>[FR] UTILISATIONS THÉRAPEUTIQUES DE COMPOSÉS PYRAZOLOPYRIMIDINE SÉLECTIONNÉS PRÉSENTANT UNE ACTIVITÉ ANTI-TYROSINE KINASE MER
  申请人：UNIV NORTH CAROLINA

  公开号：WO2015157125A1

  公开（公告）日：2015-10-15

  Pyrazolopyrimidine compounds, methods of use, and processes for making compounds with anti-Mer tyrosine kinase activity comprising Formula I, II, III, IV, or a pharmaceutically acceptable composition, salt, isotopic analog, or prodrug thereof, are provided. The pyrazolopyrimidine compounds described herein have Mer tyrosine kinase (MerTK) inhibitory activity and are useful as anti-infective agents, immunostimulatory and immunomodulatory agents, anti-cancer agents (including against MerTK -/- tumors and ITD and TKD mutant forms of Acute Myeloid Leukemia (AML)), and as adjunctive agents in combination with chemotherapeutic, radiation or other standard of care for neoplasms.