norleucylaspartic acid, H-Nle-Asp-OH | 36360-66-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: norleucylaspartic acid, H-Nle-Asp-OH
• 英文别名: 2-(2-Aminohexanoylamino)butanedioic acid
• CAS: 36360-66-4
• 化学式: C₁₀H₁₈N₂O₅
• mdl: MFCD23601449
• 分子量: 246.263
• InChiKey: QZQJHZKAIMGRFZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.7
• 重原子数：
  17
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  130
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• RADIOLABELING METHOD USING MULTIVALENT GLYCOLIGANDS AS HEPATIC RECEPTOR IMAGING AGENT
  申请人：Wang Mei-Hui

  公开号：US20110097264A1

  公开（公告）日：2011-04-28

  A radiolabeling method using a multivalent glycoligand as hepatic receptor imaging agent is provided. The multivalent glycoligand-DTPA derivatives (In-111-DTPA-hexa lactoside and In-111-DTPA-tri-galactosamine glycoside) labeled with In-111 are used as hepatic receptor imaging agent. The effects of imaging of a hepatic receptor in different species are evaluated, the lowest specific radioactivity values of hepatic receptor imaging required in different species are discovered. Since the specificity of the human ASGPR closely resembles that of the mouse. This kind of radiolabelling method, agent and related study about specific radioactivity could be used in clinical trial in the future.
• QUANTIFICATION METHOD FOR REMAINING LIVER FUNCTION AND NOVEL LIVER RECEPTOR IMAGING AGENT
  申请人：Wang Mei-Hui

  公开号：US20110097265A1

  公开（公告）日：2011-04-28

  A test indicator for quantifying remaining liver function is provided. A novel liver receptor imaging agent with liver targeting property is utilized to develop a method for quantifying remaining liver function to serve as test indicator for judging the liver failure outcome in clinic, particularly for judging the necessity of liver transplantation for patients with liver failure or liver disease. The radioactivity uptake of the test indicator was negatively correlated with the extent of liver reserve. The cutoff value of liver reserve for liver transplantation is also disclosed.
• US8435491B2
  申请人：——

  公开号：US8435491B2

  公开（公告）日：2013-05-07
• US9409939B2
  申请人：——

  公开号：US9409939B2

  公开（公告）日：2016-08-09