3-(4-ethoxyphenyl)-1,4-dihydro-4-oxo-5-cyclopentylamino-1,6-naphthyridine | 1236064-73-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 3-(4-ethoxyphenyl)-1,4-dihydro-4-oxo-5-cyclopentylamino-1,6-naphthyridine
• 英文别名: 5-(cyclopentylamino)-3-(4-ethoxyphenyl)-1H-1,6-naphthyridin-4-one
• CAS: 1236064-73-5
• 化学式: C₂₁H₂₃N₃O₂
• 分子量: 349.433
• InChiKey: CRJSHKGYKVPXKO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  63.2
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• alpha-7 Nicotinic Acetylcholine Receptor Allosteric Modulators, Their Derivatives and Uses Thereof
  申请人：Kanner Richard

  公开号：US20100190819A1

  公开（公告）日：2010-07-29

  The present application is related to compounds represented by Formula I, which are novel allosteric modulators of α7nAChR. The application also discloses the treatment of disorders that are responsive to modulation of acetylcholine action on α7nAChR in a mammal by administering an effective amount of a compound of Formula I.

  本申请涉及由公式I所代表的化合物，它们是α7nAChR的新型变构调节剂。该申请还披露了通过给哺乳动物施加公式I化合物的有效量来治疗对乙酰胆碱作用于α7nAChR敏感的疾病。
• Alpha-7 Nicotinic Acetylcholine Receptor Allosteric Modulators, Their Derivatives and Uses Thereof
  申请人：Anvyl LLC

  公开号：US20140194462A1

  公开（公告）日：2014-07-10

  The present application is related to compounds represented by Formula I, which are novel allosteric modulators of α7nAChR. The application also discloses the treatment of disorders that are responsive to modulation of acetylcholine action on α7nAChR in a mammal by administering an effective amount of a compound of Formula I.

  本申请涉及由公式I表示的化合物，它们是α7nAChR的新型变构调节剂。该申请还披露了通过给哺乳动物投与公式I化合物的有效量来调节乙酰胆碱对α7nAChR的作用，从而治疗对调节乙酰胆碱作用敏感的疾病。
• ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR ALLOSTERIC MODULATORS, THEIR DERIVATIVES AND USES THEREOF
  申请人：Anvyl, LLC

  公开号：EP2387575A1

  公开（公告）日：2011-11-23
• US8563579B2
  申请人：——

  公开号：US8563579B2

  公开（公告）日：2013-10-22
• US8975407B2
  申请人：——

  公开号：US8975407B2

  公开（公告）日：2015-03-10